The tooth exposome in children’s health research

Details

• Alternative Title:
  Curr Opin Pediatr
• Personal Author:
  Andra, Syam S. ; Austin, Christine ; Arora, Manish
• Description:
  Purpose of review
  
  The exposome concept proposes a comprehensive assessment of environmental exposures from the prenatal period onwards. However, determining exposure timing especially over the prenatal period is a major challenge in environmental epidemiologic studies.
  
  Recent findings
  
  For decades teeth have been used to estimate long-term cumulative exposure to metals. Recently developed high-dimensional analytical methods that combine sophisticated histological and chemical analysis to precisely sample tooth layers that correspond to specific life stages have the potential to reconstruct the exposome in the second and third trimesters of prenatal development and during early childhood.
  
  Summary
  
  A retrospective temporal exposomic approach that precisely measures exposure intensity and timing during prenatal and early childhood development would substantially aid epidemiologic investigations, particularly case–control studies of rare health outcomes.
  
  
• Subjects:
  Biomarkers Environmental Exposure Environmental Monitoring Environmental Pollutants Female Humans Metals Pregnancy Prenatal Exposure Delayed Effects Tooth, Deciduous
• Source:
  Curr Opin Pediatr. 28(2):221-227.
• Pubmed ID:
  26859286
• Pubmed Central ID:
  PMC4949598
• Document Type:
  Journal Article
• Funding:
  DP2 ES025453/ES/NIEHS NIH HHS/United States ; R00 ES019597/ES/NIEHS NIH HHS/United States ; DP2ES025453/DP/NCCDPHP CDC HHS/United States ; R00ES019597/ES/NIEHS NIH HHS/United States
• Volume:
  28
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:94ded7faf164fab1996357cfd6b72b32f9e0331ed58c7e5065875f2d3634c3d0
• Download URL:
  https://stacks.cdc.gov/view/cdc/40358/cdc_40358_DS1.pdf
• File Type:
  [PDF - 317.57 KB ]