The tooth exposome in children’s health research

Andra, Syam S.; Austin, Christine; Arora, Manish

doi:10.1097/MOP.0000000000000327

Back to Previous Page

The tooth exposome in children’s health research

Published Date:

Apr 2016

Publisher's site:

http://dx.doi.org/10.1097/MOP.0000000000000327

Source:

Curr Opin Pediatr. 28(2):221-227.

[PDF-317.57 KB]

Details:

Alternative Title:

Curr Opin Pediatr

Personal Author:

Andra, Syam S. ; Austin, Christine ; Arora, Manish ;

Description:

Purpose of review The exposome concept proposes a comprehensive assessment of environmental exposures from the prenatal period onwards. However, determining exposure timing especially over the prenatal period is a major challenge in environmental epidemiologic studies. Recent findings For decades teeth have been used to estimate long-term cumulative exposure to metals. Recently developed high-dimensional analytical methods that combine sophisticated histological and chemical analysis to precisely sample tooth layers that correspond to specific life stages have the potential to reconstruct the exposome in the second and third trimesters of prenatal development and during early childhood. Summary A retrospective temporal exposomic approach that precisely measures exposure intensity and timing during prenatal and early childhood development would substantially aid epidemiologic investigations, particularly case–control studies of rare health outcomes.

Subject:

[+]

Pubmed ID:

26859286

Pubmed Central ID:

PMC4949598

Document Type:

Journal Article

Funding:

DP2 ES025453/ES/NIEHS NIH HHS/United States ; R00 ES019597/ES/NIEHS NIH HHS/United States ; DP2ES025453/DP/NCCDPHP CDC HHS/United States ; R00ES019597/ES/NIEHS NIH HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

	nihms770461.nxml	application/octet-stream
	nihms770461f1.gif	image/gif
	nihms770461f1.jpg	image/jpeg

No Related Documents.

Tooth Matrix Analysis for Biomonitoring of Organic Chemical Exposure: Current Status, Challenges, and Opportunities

[PDF - 560.27 KB]

Personal Author:

Andra, Syam S. ; Austin, Christine ; ...

Published Date:

Jul 25 2015

Source:

Environ Res. 142:387-406.

Description:

Epidemiological evidence supports associations between prenatal exposure to environmental organic chemicals and childhood health impairments. Unlike t...

File Type:

[PDF - 560.27 KB]

File Type:

[PDF - 560.27 KB]
Multi-elemental bio-imaging of tissues in children's environmental health research

[PDF - 610.50 KB]

Personal Author:

Austinc, Christine ; Niedzwiecki, Megan M. ; ...

Published Date:

Apr 2016

Source:

Curr Opin Pediatr. 28(2):216-220

Description:

Purpose of reviewMetals play major roles in children's health and are associated with negative health outcomes via deficiency, overload or toxicity. C...

File Type:

[PDF - 610.50 KB]

File Type:

[PDF - 610.50 KB]
In utero metal exposures measured in deciduous teeth and birth outcomes in a racially-diverse urban cohort

[PDF - 784.16 KB]

Personal Author:

Cassidy-Bushrow, Andrea E. ; Wu, Kuan-Han Hank ; ...

Published Date:

January 31 2019

Source:

Environ Res. 171:444-451

Description:

A growing number of studies have examined associations of metal exposures with birth outcomes, however, results from these studies have been inconsist...

File Type:

[PDF - 784.16 KB]

File Type:

[PDF - 784.16 KB]
Metal exposures in an electronic scrap recycling facility

[PDF - 5.40 MB]

Personal Author:

Page, Elena H. ; Ceballos, Diana ; ...

Corporate Authors:

National Institute for Occupational Safety and Health.

Published Date:

January 2015

Series:

NIOSH health hazard evaluation report ; HETA 2013-0067-3228

Description:

The Health Hazard Evaluation Program received a request from a manager at an electronic scrap (e-scrap) recycling company. The request concerned poten...

File Type:

[PDF - 5.40 MB]

File Type:

[PDF - 5.40 MB]
Maternal-infant biomarkers of prenatal exposure to arsenic and manganese

[PDF - 2.10 MB]

Personal Author:

Rodrigues, Ema G. ; Kile, Molly ; ...

Published Date:

2015 Nov-Dec

Source:

J Expo Sci Environ Epidemiol. 25(6):639-648.

Description:

Because arsenic (As) and manganese (Mn) are able to pass the placenta, infants among exposed populations may be exposed to considerable levels in uter...

File Type:

[PDF - 2.10 MB]

File Type:

[PDF - 2.10 MB]

The tooth exposome in children’s health research

The tooth exposome in children’s health research

You May Also Like:

Have Questions?

CDC INFORMATION

CONNECT WITH CDC