Welcome to CDC Stacks | Dissecting How CD4 T Cells Are Lost During HIV Infection - 40282 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Dissecting How CD4 T Cells Are Lost During HIV Infection
Filetype[PDF - 1.05 MB]


Details:
  • Pubmed ID:
    26962940
  • Pubmed Central ID:
    PMC4835240
  • Description:
    Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highlighted how abortive infection of resting and thus nonpermissive CD4 T cells in lymphoid tissues triggers a lethal innate immune response against the incomplete DNA products generated by inefficient viral reverse transcription in these cells. Sensing of these DNA fragments results in pyroptosis, a highly inflammatory form of programmed cell death, that potentially further perpetuates chronic inflammation and immune activation. As discussed here, these studies cast CD4 T cell death during HIV infection in a different light. Further, they identify drug targets that may be exploited to both block CD4 T cell demise and the chronic inflammatory response generated during pyroptosis.

  • Document Type:
  • Collection(s):
  • Funding:
    1DP1036502/DP/NCCDPHP CDC HHS/United States
    P30 AI027763/AI/NIAID NIH HHS/United States
    R21 AI102782/AI/NIAID NIH HHS/United States
    U19 AI0961133/AI/NIAID NIH HHS/United States
    U19 AI096113/AI/NIAID NIH HHS/United States
    R21AI102782/AI/NIAID NIH HHS/United States
    DP1 DA036502/DA/NIDA NIH HHS/United States
No Related Documents.
You May Also Like: