Welcome to CDC Stacks | Dissecting How CD4 T Cells Are Lost During HIV Infection - 40282 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Dissecting How CD4 T Cells Are Lost During HIV Infection
Filetype[PDF - 1.05 MB]


Details:
  • Personal Authors:
  • Keywords:
  • Pubmed ID:
    26962940
  • Pubmed Central ID:
    PMC4835240
  • Description:
    Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highlighted how abortive infection of resting and thus nonpermissive CD4 T cells in lymphoid tissues triggers a lethal innate immune response against the incomplete DNA products generated by inefficient viral reverse transcription in these cells. Sensing of these DNA fragments results in pyroptosis, a highly inflammatory form of programmed cell death, that potentially further perpetuates chronic inflammation and immune activation. As discussed here, these studies cast CD4 T cell death during HIV infection in a different light. Further, they identify drug targets that may be exploited to both block CD4 T cell demise and the chronic inflammatory response generated during pyroptosis.

  • Document Type:
    Journal Article
  • Collection(s):
    CDC Public Access
  • Funding:
    1DP1036502/DP/NCCDPHP CDC HHS/United States
    P30 AI027763/AI/NIAID NIH HHS/United States
    R21 AI102782/AI/NIAID NIH HHS/United States
    U19 AI0961133/AI/NIAID NIH HHS/United States
    U19 AI096113/AI/NIAID NIH HHS/United States
    R21AI102782/AI/NIAID NIH HHS/United States
    DP1 DA036502/DA/NIDA NIH HHS/United States
No Related Documents.
You May Also Like:
  1. Blood-Derived CD4 T Cells Naturally Resist Pyroptosis During Abortive HIV-1 Infection
    Personal Author:
    Muñoz-Arias, Isa; Doitsh, Gilad; Yang, Zhiyuan; Sowinski, Stefanie; Ruelas, Debbie; Greene, Warner C.;
    Published:
    Oct 14 2015
    Source:
    Cell Host Microbe. 18(4):463-470.
    Description:
    Progression to AIDS is driven by CD4 T cell depletion, mostly involving pyroptosis elicited by abortive HIV infection of CD4 T cells in lymphoid tissues. Inefficient reverse transcription in these cells leads to cytoplasmic accumulation of viral DNAs...
    File Type:
    Filetype[PDF - 906.25 KB]
  2. Relaxation of Adaptive Evolution during the HIV-1 Infection Owing to Reduction of CD4+ T Cell Counts
    Personal Author:
    Leal, Élcio; Casseb, Jorge; Hendry, Michael; Busch, Michael P.; Diaz, Ricardo Sobhie;
    Published:
    Jun 29 2012
    Source:
    PLoS One. 2012; 7(6).
    Description:
    Background : The first stages of HIV-1 infection are essential to establish the diversity of virus population within host. It has been suggested that adaptation to host cells and antibody evasion are the leading forces driving HIV evolution at the in...
    File Type:
    Filetype[PDF - 566.26 KB]
  3. IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T-cells Abortively Infected with HIV
    Personal Author:
    Monroe, Kathryn M.; Yang, Zhiyuan; Johnson, Jeffrey R.; Geng, Xin; Doitsh, Gilad; Krogan, Nevan J.; Greene, Warner C.;
    Published:
    Dec 19 2013
    Source:
    Science. 343(6169):428-432.
    Description:
    The progressive depletion of quiescent "bystander" CD4 T cells, which are nonpermissive to HIV infection, is a principal driver of the acquired immunodeficiency syndrome (AIDS). These cells undergo abortive infection characterized by the cytosolic ac...
    File Type:
    Filetype[PDF - 595.81 KB]
  4. Pyroptosis drives CD4 T-cell depletion in HIV-1 infection
    Personal Author:
    Doitsh, Gilad; Galloway, Nicole LK; Geng, Xin; Yang, Zhiyuan; Monroe, Kathryn M.; Zepeda, Orlando; Hunt, Peter W.; Hatano, Hiroyu; Sowinski, Stefanie; Muñoz-Arias, Isa; Greene, Warner C.;
    Published:
    Jan 23 2014
    Source:
    Nature. 505(7484):509-514.
    Description:
    The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism. We now show that caspase-3-mediated apoptosis accounts for the death of only a small fraction of CD4 T cells...
    File Type:
    Filetype[PDF - 1.57 MB]
  5. Cell-to-cell transmission of HIV-1 is required to trigger pyroptotic death of lymphoid tissue-derived CD4 T cells
    Personal Author:
    Galloway, Nicole LK; Doitsh, Gilad; Monroe, Kathryn M.; Yang, Zhiyuan; Muñoz-Arias, Isa; Levy, David N; Greene, Warner C.;
    Published:
    Aug 28 2015
    Source:
    Cell Rep. 12(10):1555-1563.
    Description:
    The progressive depletion of CD4 T cells underlies clinical progression to AIDS in untreated HIV-infected subjects. Most dying CD4 T cells correspond to resting nonpermissive cells residing in lymphoid tissues. Death is due to an innate immune respon...
    File Type:
    Filetype[PDF - 2.13 MB]