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Dissecting How CD4 T Cells Are Lost During HIV Infection
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    Although the replicative life cycle of HIV within CD4 T cells is understood in molecular detail, less is known about how this human retrovirus promotes the loss of CD4 T lymphocytes. It is this cell death process that drives clinical progression to acquired immune deficiency syndrome (AIDS). Recent studies have highlighted how abortive infection of resting and thus nonpermissive CD4 T cells in lymphoid tissues triggers a lethal innate immune response against the incomplete DNA products generated by inefficient viral reverse transcription in these cells. Sensing of these DNA fragments results in pyroptosis, a highly inflammatory form of programmed cell death, that potentially further perpetuates chronic inflammation and immune activation. As discussed here, these studies cast CD4 T cell death during HIV infection in a different light. Further, they identify drug targets that may be exploited to both block CD4 T cell demise and the chronic inflammatory response generated during pyroptosis.

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    1DP1036502/DP/NCCDPHP CDC HHS/United States
    P30 AI027763/AI/NIAID NIH HHS/United States
    R21 AI102782/AI/NIAID NIH HHS/United States
    U19 AI0961133/AI/NIAID NIH HHS/United States
    U19 AI096113/AI/NIAID NIH HHS/United States
    R21AI102782/AI/NIAID NIH HHS/United States
    DP1 DA036502/DA/NIDA NIH HHS/United States
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