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Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases
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Details:
  • Pubmed ID:
    26850128
  • Pubmed Central ID:
    PMC4789138
  • Description:
    Small molecule secondary metabolites produced by organisms such as plants, bacteria, and fungi form a fascinating and important group of natural products, many of which have shown promise as medicines. Fungi in particular have been important sources of natural product polyketide pharmaceuticals. While the structural complexity of these polyketides makes them interesting and useful bioactive compounds, these same features also make them difficult and expensive to prepare and scale-up using synthetic methods. Currently, nearly all commercial polyketides are prepared through fermentation or semi-synthesis. However, elucidation and engineering of polyketide pathways in the native filamentous fungi hosts are often hampered due to a lack of established genetic tools and of understanding of the regulation of fungal secondary metabolisms. Saccharomyces cerevisiae has many advantages beneficial to the study and development of polyketide pathways from filamentous fungi due to its extensive genetic toolbox and well-studied metabolism. This review highlights the benefits S. cerevisiae provides as a tool for mining, studying, and engineering fungal polyketide synthases (PKSs), as well as notable insights this versatile tool has given us into the mechanisms and products of fungal PKSs.

  • Document Type:
  • Collection(s):
  • Funding:
    DP1 GM106413/GM/NIGMS NIH HHS/United States
    U01 GM110706/GM/NIGMS NIH HHS/United States
    1 U01 GM110706/GM/NIGMS NIH HHS/United States
    5 DP1 GM106413/DP/NCCDPHP CDC HHS/United States
    2 R01 GM085128/GM/NIGMS NIH HHS/United States
    T32 GM067555/GM/NIGMS NIH HHS/United States
    2 T32 GM067555/GM/NIGMS NIH HHS/United States
    R01 GM085128/GM/NIGMS NIH HHS/United States
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