Details:

Alternative Title:
J Allergy (Cairo)
Personal Author:
Anderson, Stacey E. ; Siegel, Paul D. ; Meade, B. J.
Anderson, Stacey E. ; Siegel, Paul D. ; Meade, B. J. Less -
Description:
Allergic contact dermatitis is the second most commonly reported occupational illness, accounting for 10% to 15% of all occupational diseases. This highlights the importance of developing rapid and sensitive methods for hazard identification of chemical sensitizers. The murine local lymph node assay (LLNA) was developed and validated for the identification of low molecular weight sensitizing chemicals. It provides several benefits over other tests for sensitization because it provides a quantitative endpoint, dose-responsive data, and allows for prediction of potency. However, there are also several concerns with this assay including: levels of false positive responses, variability due to vehicle, and predictivity. This report serves as a concise review which briefly summarizes the progress, advances and limitations of the assay over the last decade.
Subject:
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Review Article

Source:
J Allergy (Cairo). 2011; 2011.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:fd645678b312c35719171f87ff01ba24a9da95a3a2c8767417f432defe66c614
File Type:

Supporting Files

• 	JA2011-424203.nxml	txt
  	license.txt	txt

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