Cuffing-based photoacoustic flowmetry in humans in the optical diffusive regime

Details

• Alternative Title:
  J Biophotonics
• Personal Author:
  Zhou, Yong ; Liang, Jinyang ; Wang, Lihong V.
• Description:
  Measuring blood flow speed in the optical diffusive regime in humans has been a long standing challenge for photoacoustic tomography. In this work, we proposed a cuffing-based method to quantify blood flow speed in humans with a handheld photoacoustic probe. By cuffing and releasing the blood vessel, we can measure the blood flow speed downstream. In phantom experiments, we demonstrated that the minimum and maximum measurable flow speeds were 0.035 mm/s and 42 mm/s, respectively. In human experiments, flow speeds were measured in three different blood vessels: a radial artery in the right forearm, a radial artery in the index finger of the right hand, and a radial vein in the right forearm. Taking advantage of the handheld probe, our method can potentially be used to monitor blood flow speed in the clinic and at the bedside.
• Subjects:
  Article Blood Flow Cuffing Diffusion Hemorheology Humans In Human Optical Diffusive Regime Optical Phenomena Phantoms, Imaging Photoacoustic Techniques Photoacoustic Tomography Radial Artery

  More +
• Source:
  J Biophotonics. 9(3):208-212.
• Pubmed ID:
  26515158
• Pubmed Central ID:
  PMC4775313
• Document Type:
  Journal Article
• Funding:
  R01 EB016963/EB/NIBIB NIH HHS/United States ; R01 CA159959/CA/NCI NIH HHS/United States ; R01 CA186567/CA/NCI NIH HHS/United States ; S10 RR026922/RR/NCRR NIH HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States ; DP1 EB016986/DP/NCCDPHP CDC HHS/United States
• Volume:
  9
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:07cdf4bb6d955cb7bf110466a04b877aa47e47b22af327ad4deffaff6470a85b
• Download URL:
  https://stacks.cdc.gov/view/cdc/40155/cdc_40155_DS1.pdf
• File Type:
  [PDF - 739.15 KB ]