Details:

Alternative Title:
BMC Infect Dis
Publisher's site:
http://dx.doi.org/10.1186/s12879-016-1614-z
Personal Author:
Zhang, Tao ; Zhang, Jun ; Hua, Jun ; Wang, Dan ; Chen, Liling ; ... More +
Zhang, Tao ; Zhang, Jun ; Hua, Jun ; Wang, Dan ; Chen, Liling ; Ding, Yunfang ; Zeng, Shanshan ; Wu, Jing ; Jiang, Yanwei ; Geng, Qian ; Zhou, Suizan ; Song, Ying ; Iuliano, A. Danielle ; Greene, Carolyn M. ; McFarland, Jeffrey ; Zhao, Genming Less -
Description:
Background

The disease burden of influenza in China has not been well described, especially among young children. The aim of this study was to estimate the incidence of outpatient visits associated with influenza in young children in Suzhou, a city of more than 11 million residents in Jiangsu Province in eastern China.

Methods

Influenza-like illness (ILI) was defined as the presence of fever (axillary temperature ≥38 °C) and cough or sore throat. We collected throat swabs for children less than 5 years of age with ILI who visited Suzhou University Affiliated Children’s Hospital (SCH) outpatient clinic or emergency room between April 2011 and March 2014. Suzhou CDC, a national influenza surveillance network laboratory, tested for influenza viruses by real-time reverse transcription-polymerase chain reaction assay (rRT-PCR). Influenza-associated ILI was defined as ILI with laboratory-confirmed influenza by rRT-PCR. To calculate the incidence of influenza-associated outpatient visits, we conducted community-based healthcare utilization surveys to determine the proportion of hospital catchment area residents who sought care at SCH.

Results

The estimated incidence of influenza-associated ILI outpatient visits among children aged <5 years in the catchment area of Suzhou was, per 100 population, 17.4 (95 % CI 11.0–25.3) during April 2011-March 2012, 14.6 (95 % CI 5.2–26.2) during April 2012-March 2013 and 21.4 (95 % CI: 10.9–33.5) during April 2013-March 2014. The age-specific outpatient visit rates of influenza-associated ILI were 4.9, 21.1 and 21.2 per 100 children aged 0- <6 months, 6- <24 months and 24- <60 months, respectively.

Conclusion

Influenza virus infection causes a substantial burden of outpatient visits among young children in Suzhou, China. Targeted influenza prevention and control strategies for young children in Suzhou are needed to reduce influenza-associated outpatient visits in this age group.


Subject:
[+]
Ambulatory Care
Child
Child, Preschool
Cough
Emergency Service, Hospita
Female
Fever
Hospitals, Pediatric
Humans
Incidence
Infant
Infant, Newborn
Influenza, Human
Laboratories
Male
Orthomyxoviridae
Outpatient Clinics, Hospital
Patient Acceptance Of Health Care
Pharyngitis
Real-Time Polymerase Chain Reaction
Research Article
Reverse Transcriptase Polymerase Chain Reaction
Specimen Handling

Source:
BMC Infect Dis. 16.
Pubmed ID:
27287453
Pubmed Central ID:
PMC4901396
Document Type:
Journal Article
Place as Subject:
China
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:caa0d8c7683482816cdbec3b634263060d65daba5a422f8999c5b5ad9cbaba6c
File Type:

Supporting Files

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