A Study Update of Mortality in Workers at a Phosphate Fertilizer Production Facility

Yiin, James H.; Daniels, Robert D.; Kubale, Travis L.; Dunn, Kevin L.; Stayner, Leslie T.

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A Study Update of Mortality in Workers at a Phosphate Fertilizer Production Facility

Published Date:

Nov 02 2015

Source:

Am J Ind Med. 59(1):12-22

Language:

English

[PDF-122.01 KB]

Details:

Alternative Title:

Am J Ind Med

Personal Author:

Yiin, James H. ; Daniels, Robert D. ; Kubale, Travis L. ; Dunn, Kevin L. ; Stayner, Leslie T. ;

Description:

Objective To evaluate the mortality experience among 3,199 workers employed 1951–1976 at a phosphate fertilizer production plant in central Florida with follow-up through2011. Methods Cause-specific standardized mortality ratios (SMRs) for the full cohort were calculated with the U.S. population as referent. Lung cancer and leukemia risks were further analyzed using conditional logistic regression. Results The mortality due to all-causes (SMR = 1.07, 95% confidence interval [CI] 1.02–1.13, observed deaths [n] = 1,473), all-cancers (SMR = 1.16, 95%CI 1.06–1.28, n = 431), and a priori outcomes of interests including lung cancer (SMR = 1.32, 95%CI = 1.13–1.53, n = 168) and leukemia (SMR = 1.74, 95%CI = 1.11–2.62, n = 23) were statistically significantly elevated. Regression modeling on employment duration or estimated radiation scores did not show exposure–response relation with lung cancer or leukemia mortality. Conclusion SMR results showed increased lung cancer and leukemia mortality in a full cohort of the phosphate fertilizer production facility. There was, however, no exposure–response relation observed among cases and matched controls.

Subject:

[+]

Pubmed ID:

26523937

Pubmed Central ID:

PMC4913354

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

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Supporting Files:

nihms-794481.nxml

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