A study update of mortality in workers at a phosphate fertilizer production facility

Details

• Personal Author:
  Daniels, Robert D. ; Dunn, Kevin L. ; Kubale, Travis L. ; Stayner, Leslie T. ; Yiin JH
• Description:
  Objective: To evaluate the mortality experience among 3,199 workers employed 1951-1976 at a phosphate fertilizer production plant in central Florida with follow-up through 2011. Methods: Cause-specific standardized mortality ratios (SMRs) for the full cohort were calculated with the U.S. population as referent. Lung cancer and leukemia risks were further analyzed using conditional logistic regression. Results: The mortality due to all-causes (SMR=1.07, 95% confidence interval [CI] 1.02-1.13, observed deaths [n]=1,473), all-cancers (SMR=1.16, 95%CI 1.06-1.28, n=431), and a priori outcomes of interests including lung cancer (SMR=1.32, 95% CI=1.13-1.53, n=168) and leukemia (SMR=1.74, 95%CI=1.11-2.62, n=23) were statistically significantly elevated. Regression modeling on employment duration or estimated radiation scores did not show exposure-response relation with lung cancer or leukemia mortality. Conclusion: SMR results showed increased lung cancer and leukemia mortality in a full cohort of the phosphate fertilizer production facility. There was, however, no exposure-response relation observed among cases and matched controls. [Description provided by NIOSH]
• Subjects:
  Fertilizers Lung Lung Diseases Men Morbidity Mortality Neoplasms Occupational Health Phosphoric Acids Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Women Workplace

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• Keywords:
  Author Keywords: Phosphate Fertilizer Production Cancer Exposure-levels Exposure-response Fertilizer-industry Humans Leukemia Lung-cancer Lung Cancer Models Morbidity-rates Mortality-rates Occupational Epidemiology Phosphates Risk-factors Standardized Mortality Ratios Statistical-analysis Work-environment Workers

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  12-22
• Volume:
  59
• Issue:
  1
• NIOSHTIC Number:
  nn:20046951
• Citation:
  Am J Ind Med 2016 Jan; 59(1):12-22
• Contact Point Address:
  James H. Yiin, PhD, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 1090 Tusculum Ave, MailStop R-15, Cincinnati, OH 45226
• Email:
  jcy5@cdc.gov
• Federal Fiscal Year:
  2016
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e65e44f7983d427af9d2ff8ee06a8a4fb35fedb687d531238721bef4795248218ee5472b6c924d308f7452106cd5fafe5febb392c4588975aa4b599559e7f46d
• Download URL:
  https://stacks.cdc.gov/view/cdc/202205/cdc_202205_DS1.pdf
• File Type:
  [PDF - 118.92 KB ]