Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Publisher's site:
http://dx.doi.org/10.1002/bdra.23471
Personal Author:
Carmichael, Suzan L. ; Yang, Wei ; Gilboa, Suzanne ; Ailes, Elizabeth ; Correa, Adolfo ; ... More +
Carmichael, Suzan L. ; Yang, Wei ; Gilboa, Suzanne ; Ailes, Elizabeth ; Correa, Adolfo ; Botto, Lorenzo D. ; Feldkamp, Marcia L. ; Shaw, Gary M. Less -
Corporate Authors:
National Birth Defects Prevention Study
Description:
Background

We examined whether risks of 32 birth defects were higher than expected in the presence of overweight or obese body mass index (BMI) and low diet quality, based on estimating individual and joint effects of these factors and calculating relative excess risk due to interaction.

Methods

Analyses included mothers of 20,250 cases with birth defects and 8617 population-based controls without birth defects born from 1997 to 2009 and interviewed for the National Birth Defects Prevention Study. We used logistic regression to generate adjusted odds ratios (AORs) reflecting the combined effects of BMI and diet quality. We focused analyses on 16 birth defects (n = 11,868 cases, 8617 controls) for which initial results suggested an association with BMI or diet quality.

Results

Relative to the reference group (normal weight women with not low diet quality, i.e., >lowest quartile), AORs for low diet quality among normal weight women tended to be >1, and AORs for overweight and obese women tended to be stronger among women who had low diet quality than not low diet quality. For 9/16 birth defects, AORs for obese women who had low diet quality—the group we hypothesized to have highest risk—were higher than other stratum-specific AORs. Most relative excess risk due to interactions were positive but small (<0.5), with confidence intervals that included zero.

Conclusion

These findings provide evidence for the hypothesis of highest birth defect risks among offspring to women who are obese and have low diet quality but insufficient evidence for an interaction of these factors in their contribution to risk.


Subject:
[+]
Adult
Article
Body Mass Index
Case-Control Studies
Congenital Abnormalities
Congenital Anomalies
Diet
Feeding Behavior
Female
Humans
Infant, Newborn
Logistic Models
Male
Mothers
Neural Tube Defects
Nutrition
Obesity
Odds Ratio
Pregnancy
Pregnancy Complications
Risk Factors
Obesity

Source:
Birth Defects Res A Clin Mol Teratol. 106(3):164-171.
Pubmed ID:
26663631
Pubmed Central ID:
PMC4911035
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; P30 DK056350/DK/NIDDK NIH HHS/United States ; U01 DD001033/DD/NCBDD CDC HHS/United States ; DK56350/DK/NIDDK NIH HHS/United States
CC999999/Intramural CDC HHS/United States ; P30 DK056350/DK/NIDDK NIH HHS/United States ; U01 DD001033/DD/NCBDD CDC HHS/United States ; DK56350/DK/NIDDK NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:fbd6e7403bc84cb88cdec441cd72947af7b5d7a009fe63d0f8b23b3d891f13a3
File Type:

Supporting Files

• 	NIHMS787885-supplement-Supplemental_Table.docx	docx
  	nihms787885.nxml	bin

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