Details:

Alternative Title:
Environ Res
Personal Author:
Mortensen, Mary E ; Birch, Rebecca ; Wong, Lee-Yang ; Valentin-Blasini, Liza ; Boyle, Elizabeth B. ; ... More +
Mortensen, Mary E ; Birch, Rebecca ; Wong, Lee-Yang ; Valentin-Blasini, Liza ; Boyle, Elizabeth B. ; Caldwell, Kathleen L ; Merrill, Lori S ; Moye, John ; Blount, Benjamin C Less -
Description:
The sodium iodide-symporter (NIS) mediates uptake of iodide into thyroid follicular cells. This key step in thyroid hormone synthesis is inhibited by perchlorate, thiocyanate (SCN) and nitrate (NO3) anions. When these exposures occur during pregnancy the resulting decreases in thyroid hormones may adversely affect neurodevelopment of the human fetus. Our objectives were to describe and examine the relationship of these anions to the serum thyroid indicators, thyroid stimulating hormone (TSH) and free thyroxine (FT4), in third trimester women from the initial Vanguard Study of the National Children's Study (NCS); and to compare urine perchlorate results with those in pregnant women from the National Health and Nutritional Examination Survey (NHANES). Urinary perchlorate, SCN, NO3, and iodine, serum TSH, FT4, and cotinine were measured and a food frequency questionnaire (FFQ) was administered to pregnant women enrolled in the initial Vanguard Study. We used multiple regression models of FT4 and TSH that included perchlorate equivalent concentration (PEC, which estimates combined inhibitory effects of the anions perchlorate, SCN, and NO3 on the NIS). We used multiple regression to model predictors of each urinary anion, using FFQ results, drinking water source, season of year, smoking status, and demographic characteristics. Descriptive statistics were calculated for pregnant women in NHANES 2001-2012. The geometric mean (GM) for urinary perchlorate was 4.04µg/L, for TSH 1.46mIU/L, and the arithmetic mean for FT4 1.11ng/dL in 359 NCS women. In 330 women with completed FFQs, consumption of leafy greens, winter season, and Hispanic ethnicity were significant predictors of higher urinary perchlorate, which differed significantly by study site and primary drinking water source, and bottled water was associated with higher urinary perchlorate compared to filtered tap water. Leafy greens consumption was associated with higher urinary NO3 and higher urinary SCN. There was no association between urinary perchlorate or PEC and TSH or FT4, even for women with urinary iodine <100µg/L. GM urinary perchlorate concentrations in the full sample (n=494) of third trimester NCS women (4.03µg/L) were similar to pregnant women in NHANES (3.58µg/L).
Subjects:
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Adult Antithyroid Agents Environmental Exposure Female Humans Nitrates Nutrition Surveys Perchlorates Pregnancy Trimester, Third Symporters Thiocyanates Thyroid Function Tests Thyrotropin Thyroxine Young Adult
Source:
Environ Res. 149:179-188
Pubmed ID:
27208469
Pubmed Central ID:
PMC4907850
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Name as Subject:
National Children’s Study (U.S.) ; National Health and Nutrition Examination Survey (U.S.) ; National Children’s Study (U.S.) ; National Health and Nutrition Examination Survey (U.S.)
National Children’s Study (U.S.) ; National Health and Nutrition Examination Survey (U.S.) ; National Children’s Study (U.S.) ; National Health and Nutrition Examination Survey (U.S.) Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ed893be5db76038fef6ad881d2afc2ede82f9a28ceb194631f3106721e658d2a
Download URL:
https://stacks.cdc.gov/view/cdc/39979/cdc_39979_DS1.pdf
File Type:

Supporting Files

• 	NIHMS788536-supplement-1.xlsx	xlsx
  	NIHMS788536-supplement-2.xlsx	xlsx
  	nihms788536.nxml	xml

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