at Risk for Human Immunodeficiency Virus Infection

Details

• Alternative Title:
  Infect Dis Obstet Gynecol
• Personal Author:
  Warren, Dora ; Klein, Robert S. ; Sobel, Jack ; Kieke, Burney ; Brown, William ; Schuman, Paula ; Anderson, Jean ; Cu-Uvin, Susan ; Mayer, Kenneth ; Jamieson, Denise J. ; Holmberg, Scott ; Duerr, Ann
• Description:
  Bacterial vaginosis is a common gynecologic infection that has been associated with a variety of gynecologic and obstetric complications, including pelvic inflammatory disease, postabortal infection and premature delivery. Recent studies suggest that bacterial vaginosis may increase a woman's risk for human immunodeficiency virus (HIV). We undertook this study to assess whether the prevalence and characteristics of bacterial vaginosis differed according to HIV status in high-risk US women.|Prevalence of bacterial vaginosis was assessed by Gram's stain and clinical criteria for 854 HIV-infected and 434 HIV-uninfected women enrolled in the HIV Epidemiology Research (HER) Study. Multiple logistic regression techniques were used to determine whether HIV infection independently predicted bacterial vaginosis.|Almost half (46%) the women had bacterial vaginosis by Gram's stain. The prevalence of bacterial vaginosis was 47% in the HIV-positive women compared with 44% in the HIV-negative women; this difference was not statistically significant (p = 0.36). After adjustment for other covariates, HIV-positive women were more likely than HIV-negative women to have bacterial vaginosis (odds ratio (OR) 1.31; 95% confidence interval (CI) 1.01-1.70) by Gram's stain but not by clinical criteria (OR 1.16; CI 0.87-1.55). Among HIV-positive women, use of antiretroviral drugs was associated with a lower prevalence of bacterial vaginosis (adjusted OR 0.54; Cl 0.38-0.77).|In this cross-sectional analysis of high-risk US women, HIV infection was positively correlated with bacterial vaginosis diagnosed by Gram's stain.
• Subjects:
  Adolescent Adult AIDS-Related Opportunistic Infections Cross-Sectional Studies Female Gentian Violet HIV Infections Humans Middle Aged Odds Ratio Phenazines Prevalence Risk Factors Vaginosis, Bacterial

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• Source:
  Infect Dis Obstet Gynecol. 2001; 9(3):133-141.
• Document Type:
  Journal Article
• Volume:
  9
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:12afdf735b2940784d9cb275a89b9b85d490fd7c85eed2c8c2ea58d21e10c78d
• Download URL:
  https://stacks.cdc.gov/view/cdc/3994/cdc_3994_DS1.pdf
• File Type:
  [PDF - 156.71 KB ]