Photoacoustic elastography

Details

• Alternative Title:
  Opt Lett
• Personal Author:
  Hai, Pengfei ; Yao, Junjie ; Li, Guo ; Li, Chiye ; Wang, Lihong V.
• Description:
  Elastography can noninvasively map the elasticity distribution in biological tissue, which can potentially be used to reveal disease conditions. In this Letter, we have demonstrated photoacoustic elastography by using a linear-array photoacoustic computed tomography system. The feasibility of photoacoustic elastography was first demonstrated by imaging the strains of single-layer and bilayer gelatin phantoms with various stiffness values. The measured strains agreed well with theoretical values, with an average error of less than 5.2%. Next, in vivo photoacoustic elastography was demonstrated on a mouse leg, where the fat and muscle distribution was mapped based on the elasticity contrast. We confirmed the photoacoustic elastography results by ultrasound elastography performed simultaneously.
• Subjects:
  Animals Elasticity Imaging Techniques Gelatin Lower Extremity Mice Phantoms, Imaging Photoacoustic Techniques
• Source:
  Opt Lett. 41(4):725-728
• Pubmed ID:
  26872173
• Pubmed Central ID:
  PMC4858317
• Document Type:
  Journal Article
• Funding:
  R01 CA186567/CA/NCI NIH HHSUnited States/ ; S10-RR026922/RR/NCRR NIH HHSUnited States/ ; S10 RR026922/RR/NCRR NIH HHSUnited States/ ; DP1 EB016986/EB/NIBIB NIH HHSUnited States/ ; R01-CA186567/CA/NCI NIH HHSUnited States/ ; DP1-EB016986/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  41
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:89247e721508f4bcf087f773bb8c52cb9fdb86925aac0e4357adfc2570808fbc
• Download URL:
  https://stacks.cdc.gov/view/cdc/39895/cdc_39895_DS1.pdf
• File Type:
  [PDF - 625.52 KB ]