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Photoacoustic elastography
  • Published Date:
    Feb 15 2016
  • Source:
    Opt Lett. 41(4):725-728.
Filetype[PDF-625.52 KB]

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  • Description:
    Elastography can noninvasively map the elasticity distribution in biological tissue, which can potentially be used to reveal disease conditions. In this Letter, we have demonstrated photoacoustic elastography by using a linear-array photoacoustic computed tomography system. The feasibility of photoacoustic elastography was first demonstrated by imaging the strains of single-layer and bilayer gelatin phantoms with various stiffness values. The measured strains agreed well with theoretical values, with an average error of less than 5.2%. Next, in vivo photoacoustic elastography was demonstrated on a mouse leg, where the fat and muscle distribution was mapped based on the elasticity contrast. We confirmed the photoacoustic elastography results by ultrasound elastography performed simultaneously.

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  • Funding:
    DP1 EB016986/EB/NIBIB NIH HHS/United States
    DP1-EB016986/DP/NCCDPHP CDC HHS/United States
    R01 CA186567/CA/NCI NIH HHS/United States
    R01-CA186567/CA/NCI NIH HHS/United States
    S10 RR026922/RR/NCRR NIH HHS/United States
    S10-RR026922/RR/NCRR NIH HHS/United States
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