Mercapturic acids: recent advances in their determination by liquid chromatography/mass spectrometry and their use in toxicant metabolism studies and in occupational and environmental exposure studies

Details

• Alternative Title:
  Biomarkers
• Personal Author:
  Mathias, Patricia I. ; B’Hymer, Clayton
• Description:
  This review describes recent selected HPLC/MS methods for the determination of urinary mercapturates that are useful as noninvasive biomarkers in characterizing human exposure to electrophilic industrial chemicals in occupational and environmental studies. High-performance liquid chromatography/mass spectrometry is a sensitive and specific method for analysis of small molecules found in biological fluids. In this review, recent selected mercapturate quantification methods are summarized and specific cases are presented. The biological formation of mercapturates is introduced and their use as indicators of metabolic processing of reactive toxicants is discussed, as well as future trends and limitations in this area of research.
• Keywords:
  Acetylcysteine Biomarkers Chromatography, High Pressure Liquid Environmental Exposure Humans Internal Exposure Liquid Chromatography Mass Spectrometry Mercapturic Acid Occupational Exposure Toxicant Metabolism Urinary Biomarker

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• Source:
  Biomarkers. 21(4):293-315
• Pubmed ID:
  26900903
• Pubmed Central ID:
  PMC4894522
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  21
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:5172e35e55997ea549ca071de4a154d55e733db705be004d610d16ca9ff0c37d08797fde486d5b18e55cf6205ef81d583dce3fd33febc130bae9359805525068
• Download URL:
  https://stacks.cdc.gov/view/cdc/39840/cdc_39840_DS1.pdf
• File Type:
  [PDF - 971.66 KB ]