Urinary Phthalates and Leukocyte Telomere Length: An Analysis of NHANES 1999–2002
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
i

Superseded

This Document Has Been Replaced By:

i

Retired

This Document Has Been Retired

i

Up-to-date Information

This is the latest update:

Urinary Phthalates and Leukocyte Telomere Length: An Analysis of NHANES 1999–2002
Filetype[PDF-285.59 KB]


Details:
  • Alternative Title:
    EBioMedicine
  • Personal Author:
  • Description:
    The International Agency for Research on Cancer classified the di-2-ethylhexyl phthalate (DEHP) as "possibly carcinogenic to humans". In vitro studies reported that phthalate exposure resulted in induction of several nuclear transcription factors that are activators of telomerase reverse transcriptase (TERT) and telomerase activity of the human telomerase complex. The objective of this study was to determine whether there is an association between urinary phthalate metabolites [mono-ethyl phthalate (MEP), mono-butyl phthalate (MBP), mono-(2-ethyl)-hexyl phthalate (MEHP), and mono-benzyl phthalate (MBzP) and leukocyte telomere length (LTL) in the adult population of the National Health and Nutrition Examination Survey (NHANES) 1999-2002 (n=2472). After adjustment for potential confounders, participants in the 3rd and 4th quartiles of urinary MEHP had statistically significantly longer LTL (5.34%, 95% CI: 1.31, 9.53; and 7.14%, 95% CI: 2.94, 11.63; respectively) compared to the lowest quartile, with evidence of a dose-response relationship (p-trend=0.01). The association remained when the analyses were stratified by age groups (20-39years, 40-59years, and 60years and older), and sex. Furthermore, MBP and MBzP were associated with higher LTL in older participants. The age independent association between longer LTL and MEHP (a metabolite of DEHP) might suggest a possible role of MEHP as tumor promoter.
  • Subject:
  • Pubmed ID:
    27211552
  • Pubmed Central ID:
    PMC4856743
  • Document Type:
    Journal Article
  • Collection(s):
    CDC Public Access
  • Main Document Checksum:
  • File Type:
No Related Documents.

You May Also Like:

  1. Filetype[PDF - 271.25 KB]
    Personal Author:
    Scinicariello, Franco; Buser, Melanie C.;
    Published Date:
    Nov 19 2015
    Source:
    EBioMedicine. 2(12):1974-1979.
    Description:
    Polychlorinated biphenyls (PCBs) induce the expression of the proto-oncogene c-myc which has a role in cellular growth and proliferation programs. The c-myc up-regulates the telomerase reverse transcriptase which adds the telomeres repeating sequence...
    File Type:
    Filetype[PDF - 271.25 KB]
  2. Filetype[PDF - 342.73 KB]
    Personal Author:
    Scinicariello, Franco; Buser, Melanie C.;
    Published Date:
    Jul 15 2016
    Source:
    Environ Res. 150:513-518.
    Description:
    Telomeres are repetitive DNA sequences (TTAGGG) at the end of chromosomes. Cells with critically short telomeres enter replicative senescence and apoptosis. Several in vitro studies report that antimony causes cell apoptosis in human leukocyte cell l...
    File Type:
    Filetype[PDF - 342.73 KB]
  3. Filetype[PDF - 1.77 MB]
    Personal Author:
    Ramachandran, Sumathi; Thai, Hong; Forbi, Joseph C.; Galang, Romeo Regi; Dimitrova, Zoya; Xia, Guo-liang; Lin, Yulin; Punkova, Lili T.; Pontones, Pamela R.; Gentry, Jessica; Blosser, Sara J.; Lovchik, Judith; Switzer, William M.; Teshale, Eyasu; Peters, Philip; Ward, John; Khudyakov, Yury;
    Corporate Authors:
    Hepatitis C Investigation Team
    Published Date:
    Nov 15 2018
    Source:
    EBioMedicine. 37:374-381
    Description:
    BackgroundA high prevalence (92.3%) of hepatitis C virus (HCV) co-infection among HIV patients identified during a large HIV outbreak associated with injection of oxymorphone in Indiana prompted genetic analysis of HCV strains.MethodsMolecular epidem...
    File Type:
    Filetype[PDF - 1.77 MB]
  4. Filetype[PDF - 4.60 MB]
    Personal Author:
    Lee, Min Young; Yeon, Austin; Shahid, Muhammad; Cho, Eunho; Sairam, Vikram; Figlin, Robert; Kim, Khae-Hwan; Kim, Jayoung;
    Published Date:
    Jan 13 2018
    Source:
    Oncotarget. 2018; 9(17):13231-13243.
    Description:
    Due to its tendency to recur and acquire chemoresistance quickly, bladder cancer (BC) remains to be an elusive and difficult disease. Patients with recurrent and chemoresistant BC have an extremely poor prognosis. One possible approach that may provi...
    File Type:
    Filetype[PDF - 4.60 MB]
  5. Filetype[PDF - 3.55 MB]
    Personal Author:
    Thakur, Chitra; Wolfarth, Michael; Sun, Jiaying; Zhang, Yadong; Lu, Yongju; Battelli, Lori; Porter, Dale W.; Chen, Fei;
    Published Date:
    Feb 28 2015
    Source:
    Oncotarget. 2015; 6(6):3722-3736.
    Description:
    Mineral dust-induced gene (mdig, also named Mina53) was first identified from alveolar macrophages of the coal miners with chronic lung inflammation or fibrosis, but how this gene is involved in lung diseases is poorly understood. Here we show that h...
    File Type:
    Filetype[PDF - 3.55 MB]