Welcome to CDC stacks |
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Urinary Phthalates and Leukocyte Telomere Length: An Analysis of NHANES 1999–2002
Filetype[PDF-285.59 KB]


Details:
  • Alternative Title:
    EBioMedicine
  • Personal Author:
  • Description:
    The International Agency for Research on Cancer classified the di-2-ethylhexyl phthalate (DEHP) as "possibly carcinogenic to humans". In vitro studies reported that phthalate exposure resulted in induction of several nuclear transcription factors that are activators of telomerase reverse transcriptase (TERT) and telomerase activity of the human telomerase complex. The objective of this study was to determine whether there is an association between urinary phthalate metabolites [mono-ethyl phthalate (MEP), mono-butyl phthalate (MBP), mono-(2-ethyl)-hexyl phthalate (MEHP), and mono-benzyl phthalate (MBzP) and leukocyte telomere length (LTL) in the adult population of the National Health and Nutrition Examination Survey (NHANES) 1999-2002 (n=2472). After adjustment for potential confounders, participants in the 3rd and 4th quartiles of urinary MEHP had statistically significantly longer LTL (5.34%, 95% CI: 1.31, 9.53; and 7.14%, 95% CI: 2.94, 11.63; respectively) compared to the lowest quartile, with evidence of a dose-response relationship (p-trend=0.01). The association remained when the analyses were stratified by age groups (20-39years, 40-59years, and 60years and older), and sex. Furthermore, MBP and MBzP were associated with higher LTL in older participants. The age independent association between longer LTL and MEHP (a metabolite of DEHP) might suggest a possible role of MEHP as tumor promoter.
  • Subject:
  • Pubmed ID:
    27211552
  • Pubmed Central ID:
    PMC4856743
  • Document Type:
    Journal Article
  • Collection(s):
    CDC Public Access
  • Main Document Checksum:
No Related Documents.
You May Also Like:
  1. Coming Soon
    Sources of Sodium Potassium Supplement
    Corporate Authors:
    Centers for Disease Control and Prevention (U.S.)
    Published Date:
    08/14/2020
    Series:
    MMWR. Morbidity and mortality supplementary materials
    Description:
    MMWR Supplementary Table for Volume 69 no.32
    Public Access
    Available on:
    August 11, 2020
  2. Coronavirus disease (COVID-19) cases in the U.S. : updated on August 4, 2020
    Corporate Authors:
    National Center for Immunization and Respiratory Diseases (U.S.). Division of Viral Diseases.
    Published Date:
    08/04/2020
    Series:
    Coronavirus Disease 2020 (COVID-19)
    Description:
    This page is updated daily based on data confirmed at 4:00pm ET the day before.Numbers reported on Saturdays and Sundays are preliminary and not yet confirmed by state and territorial health departments. These numbers may be modified when numbers are...
    File Type:
    Filetype[PDF - 1.33 MB]
  3. Vital signs : Clinical characteristics of patients with confirmed acute flaccid myelitis, United States, 2018
    Personal Author:
    Kidd, Sarah; Lopez, Adriana; Nix, W. Allan; Anyalechi, Gloria; Itoh, Megumi; Yee, Eileen; Oberste, M. Steven; Routh, Janell;
    Corporate Authors:
    National Center for Immunization and Respiratory Diseases (U.S.). Division of Viral Diseases.. National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.). Division of STD Prevention.. Center for Global Health (U.S.). Division of Global HIV and TB..
    Published Date:
    August 4, 2020
    Series:
    MMWR. Morbidity and mortality weekly report ; v. 69, early release, August 4, 2020
    CDC Vital signs ; AUG 2020
    Description:
    What is already known about this topic? Since U.S. surveillance for acute flaccid myelitis (AFM) began in 2014, reported cases have peaked biennially. Most cases occur in children during late summer and early fall.What is added by this report? Among ...
    File Type:
    Filetype[PDF - 274.88 KB]
  4. CDC expects 2020 outbreak of life-threatening acute flaccid myelitis : doctors urged to quickly recognize symptoms and to hospitalize patients immediately :embargoed until: Tuesday, August 4, 2020, 1:00 p.m. ET
    Corporate Authors:
    Centers for Disease Control and Prevention (U.S.)
    Published Date:
    August 4, 2020
    Description:
    The Centers for Disease Control and Prevention (CDC) anticipates that 2020 will be another peak year for cases of acute flaccid myelitis (AFM), an uncommon but serious neurologic condition that affects mostly children. The disease has peaked every tw...
    File Type:
    Filetype[PDF - 99.33 KB]
  5. Acute flaccid myelitis (AFM) : Recognize symptoms. Hospitalize immediately
    Corporate Authors:
    Centers for Disease Control and Prevention (U.S.). Office of the Associate Director for Communication.
    Published Date:
    August 4, 2020
    Series:
    CDC Vital signs ; AUG 2020
    Description:
    Acute flaccid myelitis (AFM) is an uncommon, but life-threatening neurologic condition that affects mostly children and can lead to permanent paralysis. Enteroviruses, particularly EV-D68, are likely responsible for the increase in cases every two ye...
    File Type:
    Filetype[PDF - 279.47 KB]