Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Adney, Danielle R. ; Bielefeldt-Ohmann, Helle ; Hartwig, Airn E. ; Bowen, Richard A.
Adney, Danielle R. ; Bielefeldt-Ohmann, Helle ; Hartwig, Airn E. ; Bowen, Richard A. Less -
Description:
Middle East respiratory syndrome coronavirus is a recently emerged pathogen associated with severe human disease. Zoonotic spillover from camels appears to play a major role in transmission. Because of logistic difficulties in working with dromedaries in containment, a more manageable animal model would be desirable. We report shedding and transmission of this virus in experimentally infected alpacas (n = 3) or those infected by contact (n = 3). Infectious virus was detected in all infected animals and in 2 of 3 in-contact animals. All alpacas seroconverted and were rechallenged 70 days after the original infection. Experimentally infected animals were protected against reinfection, and those infected by contact were partially protected. Necropsy specimens from immunologically naive animals (n = 3) obtained on day 5 postinfection showed virus in the upper respiratory tract. These data demonstrate efficient virus replication and animal-to-animal transmission and indicate that alpacas might be useful surrogates for camels in laboratory studies.
Subjects:
[+]
Antibodies, Neutralizing Antibodies, Viral Biopsy Camelus Coronavirus Infections Disease Models, Animal Humans Immunity, Humoral Immunohistochemistry Middle East Respiratory Syndrome Coronavirus Symptom Assessment Virus Replication Virus Shedding Zoonoses
Source:
Emerg Infect Dis. 22(6):1031-1037.
Pubmed ID:
27070385
Pubmed Central ID:
PMC4880070
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:cdf9715540c626c6515bcb0abf69c660e9a8328dc534d1343165569d6ceabe81
Download URL:
https://stacks.cdc.gov/view/cdc/39710/cdc_39710_DS1.pdf
File Type:

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