Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States

Cerar, Tjasa; Strle, Franc; Stupica, Dasa; Ruzic-Sabljic, Eva; McHugh, Gail; Steere, Allen C.; Strle, Klemen

doi:10.3201/eid2205.151806

i

Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States

Supporting Files Public Domain

May 2016
By Cerar, Tjasa ; Strle, Franc ; Stupica, Dasa ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Cerar, Tjasa ; Strle, Franc ; Stupica, Dasa ; Ruzic-Sabljic, Eva ; McHugh, Gail ; Steere, Allen C. ; Strle, Klemen
Description:

Borrelia burgdorferi sensu stricto isolates from patients with erythema migrans in Europe and the United States were compared by genotype, clinical features of infection, and inflammatory potential. Analysis of outer surface protein C and multilocus sequence typing showed that strains from these 2 regions represent distinct genotypes. Clinical features of infection with B. burgdorferi in Slovenia were similar to infection with B. afzelii or B. garinii, the other 2 Borrelia spp. that cause disease in Europe, whereas B. burgdorferi strains from the United States were associated with more severe disease. Moreover, B. burgdorferi strains from the United States induced peripheral blood mononuclear cells to secrete higher levels of cytokines and chemokines associated with innate and Th1-adaptive immune responses, whereas strains from Europe induced greater Th17-associated responses. Thus, strains of the same B. burgdorferi species from Europe and the United States represent distinct clonal lineages that vary in virulence and inflammatory potential.
Subjects:

Biomarkers Borrelia Burgdorferi Cytokines Erythema Chronicum Migrans Genotype Humans Inflammation Mediators Leukocytes, Mononuclear Multilocus Sequence Typing Phylogeny Research
Source:

Emerg Infect Dis. 22(5):818-827.
Pubmed ID:

27088349
Pubmed Central ID:

PMC4861522
Document Type:

Journal Article
Place as Subject:

Europe ; United States
Location:

Europe ; North America
Volume:

22
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:b53c83fb9a7b65d903c4088334e11e3b9f0fc7b59ad47285ad9cac3aa3700e8b
Download URL:

https://stacks.cdc.gov/view/cdc/39370/cdc_39370_DS1.pdf
File Type:

[PDF - 805.54 KB ]

File Language:

English

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