Plasmodium falciparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014

Fall, Bécaye; Madamet, Marylin; Camara, Cheikhou; Amalvict, Rémy; Fall, Mansour; Nakoulima, Aminata; Diatta, Bakary; Diémé, Yaya; Wade, Boubacar; Pradines, Bruno

doi:10.3201/eid2205.151321

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Plasmodium falciparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014

May 2016
By Fall, Bécaye ; Madamet, Marylin ; Camara, Cheikhou ; ...
http://dx.doi.org/10.3201/eid2205.151321
Source: Emerg Infect Dis. 22(5):841-845.

[PDF-341.55 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Fall, Bécaye ; Madamet, Marylin ; Camara, Cheikhou ; Amalvict, Rémy ; Fall, Mansour ; ... More +

Fall, Bécaye ; Madamet, Marylin ; Camara, Cheikhou ; Amalvict, Rémy ; Fall, Mansour ; Nakoulima, Aminata ; Diatta, Bakary ; Diémé, Yaya ; Wade, Boubacar ; Pradines, Bruno Less -
Description:

We successfully cultured 36 Plasmodium falciparum isolates from blood samples of 44 malaria patients admitted to the Hôpital Principal de Dakar (Dakar, Senegal) during August-December 2014. The prevalence of isolates with in vitro reduced susceptibility was 30.6% for monodesethylamodiaquine, 52.8% for chloroquine, 44.1% for mefloquine, 16.7% for doxycycline, 11.8% for piperaquine, 8.3% for artesunate, 5.9% for pyronaridine, 2.8% for quinine and dihydroartemisinin, and 0.0% for lumefantrine. The prevalence of isolates with reduced in vitro susceptibility to the artemisinin-based combination therapy partner monodesethylamodiaquine increased from 5.6% in 2013 to 30.6% in 2014. Because of the increased prevalence of P. falciparum parasites with impaired in vitro susceptibility to monodesethylamodiaquine, the implementation of in vitro and in vivo surveillance of all artemisinin-based combination therapy partners is warranted.
Subjects:

[+]

Amodiaquine Antimalarials Drug Resistance Female Humans Inhibitory Concentration 50 Malaria, Falciparum Male Parasitic Sensitivity Tests Plasmodium Falciparum/drug Effects Prevalence Research
Source:

Emerg Infect Dis. 22(5):841-845.
Pubmed ID:

27088703
Pubmed Central ID:

PMC4861513
Document Type:

Journal Article
Place as Subject:

Senegal
Location:

Africa
Volume:

22
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:5c5805c77deb7bf7894e09f8b3e093fa2814ec360ab07694288c3920149fd593
Download URL:

https://stacks.cdc.gov/view/cdc/39361/cdc_39361_DS1.pdf
File Type:

	15-1321.nxml	bin
	license.txt	txt

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