Assessing Local Risk of Rifampicin-Resistant Tuberculosis in KwaZulu-Natal, South Africa Using Lot Quality Assurance Sampling

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Heidebrecht, Christine L. ; Podewils, Laura J. ; Pym, Alexander ; Mthiyane, Thuli ; Cohen, Ted
• Description:
  Background
  
  KwaZulu-Natal (KZN) has the highest burden of notified multidrug-resistant tuberculosis (MDR TB) and extensively drug-resistant (XDR) TB cases in South Africa. A better understanding of spatial heterogeneity in the risk of drug-resistance may help to prioritize local responses.
  
  Methods
  
  Between July 2012 and June 2013, we conducted a two-way Lot Quality Assurance Sampling (LQAS) study to classify the burden of rifampicin (RIF)-resistant TB among incident TB cases notified within the catchment areas of seven laboratories in two northern and one southern district of KZN. Decision rules for classification of areas as having either a high- or low-risk of RIF resistant TB (based on proportion of RIF resistance among all TB cases) were based on consultation with local policy makers.
  
  Results
  
  We classified five areas as high-risk and two as low-risk. High-risk areas were identified in both Southern and Northern districts, with the greatest proportion of RIF resistance observed in the northernmost area, the Manguzi community situated on the Mozambique border.
  
  Conclusion
  
  Our study revealed heterogeneity in the risk of RIF resistant disease among incident TB cases in KZN. This study demonstrates the potential for LQAS to detect geographic heterogeneity in areas where access to drug susceptibility testing is limited.
  
  
• Subjects:
  Adolescent Adult Antitubercular Agents Female Humans Male Middle Aged Prospective Studies Quality Control Retrospective Studies Rifampin Risk Factors Sensitivity And Specificity Tuberculosis, Multidrug-Resistant Young Adult

  More +
• Source:
  PLoS One. 11(4).
• Pubmed ID:
  27050561
• Pubmed Central ID:
  PMC4822784
• Document Type:
  Journal Article
• Name as Subject:
  United States. President's Emergency Plan For AIDS Relief (PEPFAR)
• Place as Subject:
  South Africa
• Volume:
  11
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a22869188339a9655dd937da4262aa82fe29bd2a89b0817911baf463091047dbf1edf01b75d0ca2e7e1f74503685a693d40cacf360c82a60732c325f06eca11e
• Download URL:
  https://stacks.cdc.gov/view/cdc/39197/cdc_39197_DS1.pdf
• File Type:
  [PDF - 703.50 KB ]