Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia
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Published Date:Jul 2015
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Publisher's site:
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Source:Emerg Infect Dis. 21(7):1135-1143.
Details:
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Personal Authors:
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Corporate Authors:on behalf of US Army Medical Research Institute of Infectious Diseases ; National Institutes of Health ; Integrated Research Facility–Frederick Ebola Response Team 2014–2015
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Keywords:
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Pubmed ID:26079255
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Pubmed Central ID:PMC4816332
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Description:To support Liberia's response to the ongoing Ebola virus (EBOV) disease epidemic in Western Africa, we established in-country advanced genomic capabilities to monitor EBOV evolution. Twenty-five EBOV genomes were sequenced at the Liberian Institute for Biomedical Research, which provided an in-depth view of EBOV diversity in Liberia during September 2014-February 2015. These sequences were consistent with a single virus introduction to Liberia; however, shared ancestry with isolates from Mali indicated at least 1 additional instance of movement into or out of Liberia. The pace of change is generally consistent with previous estimates of mutation rate. We observed 23 nonsynonymous mutations and 1 nonsense mutation. Six of these changes are within known binding sites for sequence-based EBOV medical countermeasures; however, the diagnostic and therapeutic impact of EBOV evolution within Liberia appears to be low.
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Funding:HHSN272200700016I/PHS HHS/United States
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