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Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia
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Jul 2015
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Source: Emerg Infect Dis. 21(7):1135-1143
[PDF-2.47 MB]
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Alternative Title:Emerg Infect Dis
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Description:To support Liberia's response to the ongoing Ebola virus (EBOV) disease epidemic in Western Africa, we established in-country advanced genomic capabilities to monitor EBOV evolution. Twenty-five EBOV genomes were sequenced at the Liberian Institute for Biomedical Research, which provided an in-depth view of EBOV diversity in Liberia during September 2014-February 2015. These sequences were consistent with a single virus introduction to Liberia; however, shared ancestry with isolates from Mali indicated at least 1 additional instance of movement into or out of Liberia. The pace of change is generally consistent with previous estimates of mutation rate. We observed 23 nonsynonymous mutations and 1 nonsense mutation. Six of these changes are within known binding sites for sequence-based EBOV medical countermeasures; however, the diagnostic and therapeutic impact of EBOV evolution within Liberia appears to be low.
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Pubmed ID:26079255
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Pubmed Central ID:PMC4816332
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Volume:21
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Issue:7
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