Transcriptional Pathways Altered in Response to Vibration in a Model of Hand-Arm Vibration Syndrome

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Waugh, Stacey ; Kashon, Michael L. ; Li, Shengqiao ; Miller, Gerome R. ; Johnson, Claud ; Krajnak, Kristine
• Description:
  Objective
  
  The aim of this study was to use an established model of vibration-induced injury to assess frequency-dependent changes in transcript expression in skin, artery, and nerve tissues.
  
  Methods
  
  Transcript expression in tissues from control and vibration-exposed rats (4 h/day for 10 days at 62.5, 125, or 250 Hz; 49 m/s2, rms) was measured. Transcripts affected by vibration were used in bioinformatics analyses to identify molecular- and disease-related pathways associated with exposure to vibration.
  
  Results
  
  Analyses revealed that cancer-related pathways showed frequency-dependent changes in activation or inhibition. Most notably, the breast-related cancer-1 pathway was affected. Other pathways associated with breast cancer type 1 susceptibility protein related signaling, or associated with cancer and cell cycle/cell survivability were also affected.
  
  Conclusion
  
  Occupational exposure to vibration may result in DNA damage and alterations in cell signaling pathways that have significant effects on cellular division.
  
  
• Subjects:
  Animals Arteries Ataxia Telangiectasia Mutated Proteins Cell Cycle Cell Survival Computational Biology Cyclin-Dependent Kinase 5 Disease Models, Animal Hand-Arm Vibration Syndrome Male Oligonucleotide Array Sequence Analysis Peripheral Nerves Rats Rats, Sprague-Dawley RNA Signal Transduction Skin Transcription, Genetic Ubiquitin-Protein Ligases Vibration

  More +
• Source:
  J Occup Environ Med. 58(4):344-350
• Pubmed ID:
  27058473
• Pubmed Central ID:
  PMC4837947
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  58
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7a86665352e42b56fc39123da835e7eb85f40521ca34a71a14d6ebc5e1eed04b
• Download URL:
  https://stacks.cdc.gov/view/cdc/39049/cdc_39049_DS1.pdf
• File Type:
  [PDF - 827.00 KB ]