i
Transcriptional Pathways Altered in Response to Vibration in a Model of Hand-Arm Vibration Syndrome
-
4 2016
-
-
Source: J Occup Environ Med. 58(4):344-350
[PDF-827.00 KB]
Details:
-
Alternative Title:J Occup Environ Med
-
Personal Author:
-
Description:Objective
The aim of this study was to use an established model of vibration-induced injury to assess frequency-dependent changes in transcript expression in skin, artery, and nerve tissues.
Methods
Transcript expression in tissues from control and vibration-exposed rats (4 h/day for 10 days at 62.5, 125, or 250 Hz; 49 m/s2, rms) was measured. Transcripts affected by vibration were used in bioinformatics analyses to identify molecular- and disease-related pathways associated with exposure to vibration.
Results
Analyses revealed that cancer-related pathways showed frequency-dependent changes in activation or inhibition. Most notably, the breast-related cancer-1 pathway was affected. Other pathways associated with breast cancer type 1 susceptibility protein related signaling, or associated with cancer and cell cycle/cell survivability were also affected.
Conclusion
Occupational exposure to vibration may result in DNA damage and alterations in cell signaling pathways that have significant effects on cellular division.
-
Subjects:
-
Source:
-
Pubmed ID:27058473
-
Pubmed Central ID:PMC4837947
-
Document Type:
-
Funding:
-
Volume:58
-
Issue:4
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
