Details:

Alternative Title:
J Infect Dis
Personal Author:
McMorrow, Meredith L. ; Okitolonda Wemakoy, Emile ; Tshilobo, Joelle Kabamba ; Emukule, Gideon O. ; Mott, Joshua A. ; ... More +
McMorrow, Meredith L. ; Okitolonda Wemakoy, Emile ; Tshilobo, Joelle Kabamba ; Emukule, Gideon O. ; Mott, Joshua A. ; Njuguna, Henry ; Waiboci, Lilian ; Heraud, Jean-Michel ; Rajatonirina, Soatianana ; Razanajatovo, Norosoa H. ; Chilombe, Moses ; Everett, Dean ; Heyderman, Robert S. ; Barakat, Amal ; Nyatanyi, Thierry ; Rukelibuga, Joseph ; Cohen, Adam L. ; Cohen, Cheryl ; Tempia, Stefano ; Thomas, Juno ; Venter, Marietjie ; Mwakapeje, Elibariki ; Mponela, Marcelina ; Lutwama, Julius ; Duque, Jazmin ; Lafond, Kathryn ; Nzussouo, Ndahwouh Talla ; Williams, Thelma ; Widdowson, Marc-Alain Less -
Description:
Background

Data on causes of death due to respiratory illness in Africa are limited.

Methods

From January to April 2013, 28 African countries were invited to participate in a review of severe acute respiratory illness (SARI)–associated deaths identified from influenza surveillance during 2009–2012.

Results

Twenty-three countries (82%) responded, 11 (48%) collect mortality data, and 8 provided data. Data were collected from 37 714 SARI cases, and 3091 (8.2%; range by country, 5.1%–25.9%) tested positive for influenza virus. There were 1073 deaths (2.8%; range by country, 0.1%–5.3%) reported, among which influenza virus was detected in 57 (5.3%). Case-fatality proportion (CFP) was higher among countries with systematic death reporting than among those with sporadic reporting. The influenza-associated CFP was 1.8% (57 of 3091), compared with 2.9% (1016 of 34 623) for influenza virus–negative cases (P < .001). Among 834 deaths (77.7%) tested for other respiratory pathogens, rhinovirus (107 [12.8%]), adenovirus (64 [6.0%]), respiratory syncytial virus (60 [5.6%]), and Streptococcus pneumoniae (57 [5.3%]) were most commonly identified. Among 1073 deaths, 402 (37.5%) involved people aged 0–4 years, 462 (43.1%) involved people aged 5–49 years, and 209 (19.5%) involved people aged ≥50 years.

Conclusions

Few African countries systematically collect data on outcomes of people hospitalized with respiratory illness. Stronger surveillance for deaths due to respiratory illness may identify risk groups for targeted vaccine use and other prevention strategies.


Keywords:
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Adolescent Adult Africa South Of The Sahara Aged Age Distribution Bacterial Infections Child Child, Preschool Human Humans Infant Infant, Newborn Influenza Influenza, Human Middle Aged Mortality Population Surveillance Respiratory Tract Infections Young Adult
Source:
J Infect Dis. 212(6):853-860
Pubmed ID:
25712970
Pubmed Central ID:
PMC4826902
Document Type:
Journal Article
Funding:
Wellcome TrustUnited Kingdom/ ; CC999999/Intramural CDC HHSUnited States/
Wellcome TrustUnited Kingdom/ ; CC999999/Intramural CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:864ea6d34e01df7df9394917072d3fb19c01da25b4ef5ff241789b6ddcf5d19f
Download URL:
https://stacks.cdc.gov/view/cdc/38923/cdc_38923_DS1.pdf
File Type:

Supporting Files

• 	NIHMS772136-supplement-Table.docx	docx
  	nihms772136.nxml	xml

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