Details:

Alternative Title:
Environ Health Perspect
Personal Author:
Blount, Benjamin C. ; Pirkle, James L. ; Osterloh, John D. ; Valentin-Blasini, Liza ; Caldwell, Kathleen L.
Blount, Benjamin C. ; Pirkle, James L. ; Osterloh, John D. ; Valentin-Blasini, Liza ; Caldwell, Kathleen L. Less -
Description:
Background

Perchlorate is commonly found in the environment and known to inhibit thyroid function at high doses. Assessing the potential effect of low-level exposure to perchlorate on thyroid function is an area of ongoing research.

Objectives

We evaluated the potential relationship between urinary levels of perchlorate and serum levels of thyroid stimulating hormone (TSH) and total thyroxine (T4) in 2,299 men and women, ≥ 12 years of age, participating in the National Health and Nutrition Examination Survey (NHANES) during 2001–2002.

Methods

We used multiple regression models of T4 and TSH that included perchlorate and covariates known to be or likely to be associated with T4 or TSH levels: age, race/ethnicity, body mass index, estrogen use, menopausal status, pregnancy status, premenarche status, serum C-reactive protein, serum albumin, serum cotinine, hours of fasting, urinary thiocyanate, urinary nitrate, and selected medication groups.

Results

Perchlorate was not a significant predictor of T4 or TSH levels in men. For women overall, perchlorate was a significant predictor of both T4 and TSH. For women with urinary iodine < 100 μg/L, perchlorate was a significant negative predictor of T4 (p < 0.0001) and a positive predictor of TSH (p = 0.001). For women with urinary iodine ≥ 100 μg/L, perchlorate was a significant positive predictor of TSH (p = 0.025) but not T4 (p = 0.550).

Conclusions

These associations of perchlorate with T4 and TSH are coherent in direction and independent of other variables known to affect thyroid function, but are present at perchlorate exposure levels that were unanticipated based on previous studies.


Subject:
[+]
Adolescent
Adult
Age Factors
Environmental Monitoring
Female
Humans
Logistic Models
Male
Perchlorates
Socioeconomic Factors
Thyroid Hormones
Thyrotropin
Thyroxine

Source:
Environ Health Perspect. 2006; 114(12):1865-1871.
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4789a1fdda09a16e873614d3ca7d20a4988d3a7fed4ff25c3eed6524b47903a2
File Type:

Supporting Files

• 	ehp0114-001865.nxml	txt
  	license.txt	txt

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