Details:

Alternative Title:
PLoS One
Personal Author:
Zheng, Jiandong ; Huo, Xixiang ; Huai, Yang ; Xiao, Lin ; Jiang, Hui ; ... More +
Zheng, Jiandong ; Huo, Xixiang ; Huai, Yang ; Xiao, Lin ; Jiang, Hui ; Klena, John ; Greene, Carolyn M. ; Xing, Xuesen ; Huang, Jigui ; Liu, Shali ; Peng, Youxing ; Yang, Hui ; Luo, Jun ; Peng, Zhibin ; Liu, Linlin ; Chen, Maoyi ; Chen, Hui ; Zhang, Yuzhi ; Huang, Danqin ; Guan, Xuhua ; Feng, Luzhao ; Zhan, Faxian ; Hu, Dale J. ; Varma, Jay K. ; Yu, Hongjie Less -
Description:
Background

After the 2009 influenza A (H1N1) pandemic, we conducted hospital-based severe acute respiratory infection (SARI) surveillance in one central Chinese city to assess disease burden attributable to influenza among adults and adolescents.

Methods

We defined an adult SARI case as a hospitalized patient aged ≥ 15 years with temperature ≥38.0°C and at least one of the following: cough, sore throat, tachypnea, difficulty breathing, abnormal breath sounds on auscultation, sputum production, hemoptysis, chest pain, or chest radiograph consistent with pneumonia. For each enrolled SARI case-patient, we completed a standardized case report form, and collected a nasopharyngeal swab within 24 hours of admission. Specimens were tested for influenza viruses by real-time reverse transcription polymerase chain reaction (rRT-PCR). We analyzed data from adult SARI cases in four hospitals in Jingzhou, China from April 2010 to April 2012.

Results

Of 1,790 adult SARI patients enrolled, 40% were aged ≥ 65 years old. The median duration of hospitalization was 9 days. Nearly all were prescribed antibiotics during their hospitalization, less than 1% were prescribed oseltamivir, and 28% were prescribed corticosteroids. Only 0.1% reported receiving influenza vaccination in the past year. Of 1,704 samples tested, 16% were positive for influenza. Influenza activity in all age groups showed winter-spring and summer peaks. Influenza-positive patients had a longer duration from illness onset to hospitalization and a shorter duration from hospital admission to discharge or death compared to influenza negative SARI patients.

Conclusions

There is substantial burden of influenza-associated SARI hospitalizations in Jingzhou, China, especially among older adults. More effective promotion of annual seasonal influenza vaccination and timely oseltamivir treatment among high risk groups may improve influenza prevention and control in China.


Subjects:
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Acute Disease Adolescent Adult Aged Female Hospitalization Humans Influenza, Human Male Middle Aged Research Article Seasons Young Adult
Source:
PLoS One. 11(3).
Pubmed ID:
26958855
Pubmed Central ID:
PMC4784897
Document Type:
Journal Article
Funding:
5U2GGH000018/PHS HHS/United States
Place as Subject:
China
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:02b9bc3af2b97c4d615b056f32df665a18f7e265c55da55fbd784913c2cad703
Download URL:
https://stacks.cdc.gov/view/cdc/38850/cdc_38850_DS1.pdf
File Type:

Supporting Files

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