Shiga Toxin 1–Producing Shigella sonnei Infections, California, United States, 2014–2015

Lamba, Katherine; Nelson, Jennifer A.; Kimura, Akiko C.; Poe, Alyssa; Collins, Joan; Kao, Annie S.; Cruz, Laura; Inami, Gregory; Vaishampayan, Julie; Garza, Alvaro; Chaturvedi, Vishnu; Vugia, Duc J.

doi:10.3201/eid2204.151825

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Shiga Toxin 1–Producing Shigella sonnei Infections, California, United States, 2014–2015

Supporting Files Public Domain

Apr 2016
By Lamba, Katherine ; Nelson, Jennifer A. ; Kimura, Akiko C. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Lamba, Katherine ; Nelson, Jennifer A. ; Kimura, Akiko C. ; Poe, Alyssa ; Collins, Joan ; Kao, Annie S. ; Cruz, Laura ; Inami, Gregory ; Vaishampayan, Julie ; Garza, Alvaro ; Chaturvedi, Vishnu ; Vugia, Duc J.
Description:

Shiga toxins (Stx) are primarily associated with Shiga toxin-producing Escherichia coli and Shigella dysenteriae serotype 1. Stx production by other shigellae is uncommon, but in 2014, Stx1-producing S. sonnei infections were detected in California. Surveillance was enhanced to test S. sonnei isolates for the presence and expression of stx genes, perform DNA subtyping, describe clinical and epidemiologic characteristics of case-patients, and investigate for sources of infection. During June 2014-April 2015, we identified 56 cases of Stx1-producing S. sonnei, in 2 clusters. All isolates encoded stx1 and produced active Stx1. Multiple pulsed-field gel electrophoresis patterns were identified. Bloody diarrhea was reported by 71% of case-patients; none had hemolytic uremic syndrome. Some initial cases were epidemiologically linked to travel to Mexico, but subsequent infections were transmitted domestically. Continued surveillance of Stx1-producing S. sonnei in California is necessary to characterize its features and plan for reduction of its spread in the United States.
Subjects:

Adolescent Adult Anti-Bacterial Agents/therapeutic Use Child Child, Preschool Diarrhea Dysentery, Bacillary Electrophoresis, Gel, Pulsed-Field Epidemiological Monitoring Humans Infant Infant, Newborn Middle Aged Research Shiga Toxin 1 Shigella Sonnei
Source:

Emerg Infect Dis. 22(4):679-686.
Pubmed ID:

26982255
Pubmed Central ID:

PMC4806944
Document Type:

Journal Article
Place as Subject:

California
Location:

North America
Volume:

22
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:288b709ba356617821f5e2d66b4749f3f80a5ba9bfeb66686c2a7f0f262eff30
Download URL:

https://stacks.cdc.gov/view/cdc/38731/cdc_38731_DS1.pdf
File Type:

[PDF - 558.18 KB ]

File Language:

English

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