Nosocomial Co-Transmission of Avian Influenza A(H7N9) and A(H1N1)pdm09 Viruses between 2 Patients with Hematologic Disorders

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Chen, Huazhong ; Liu, Shelan ; Liu, Jun ; Chai, Chengliang ; Mao, Haiyan ; Yu, Zhao ; Tang, Yuming ; Zhu, Geqin ; Chen, Haixiao X. ; Zhu, Chengchu ; Shao, Hui ; Tan, Shuguang ; Wang, Qianli ; Bi, Yuhai ; Zou, Zhen ; Liu, Guang ; Jin, Tao ; Jiang, Chengyu ; Gao, George F. ; Peiris, Malik ; Yu, Hongjie ; Chen, Enfu
• Description:
  A nosocomial cluster induced by co-infections with avian influenza A(H7N9) and A(H1N1)pdm09 (pH1N1) viruses occurred in 2 patients at a hospital in Zhejiang Province, China, in January 2014. The index case-patient was a 57-year-old man with chronic lymphocytic leukemia who had been occupationally exposed to poultry. He had co-infection with H7N9 and pH1N1 viruses. A 71-year-old man with polycythemia vera who was in the same ward as the index case-patient for 6 days acquired infection with H7N9 and pH1N1 viruses. The incubation period for the second case-patient was estimated to be <4 days. Both case-patients died of multiple organ failure. Virus genetic sequences from the 2 case-patients were identical. Of 103 close contacts, none had acute respiratory symptoms; all were negative for H7N9 virus. Serum samples from both case-patients demonstrated strong proinflammatory cytokine secretion but incompetent protective immune responses. These findings strongly suggest limited nosocomial co-transmission of H7N9 and pH1N1 viruses from 1 immunocompromised patient to another.
• Subjects:
  Aged Animals Cross Infection Cytokines Fatal Outcome Humans Immunocompromised Host Influenza, Human Influenza A Virus, H1N1 Subtype Influenza A Virus, H7N9 Subtype Influenza In Birds Leukemia, Lymphocytic, Chronic, B-Cell Male Middle Aged Occupational Exposure Polycythemia Vera Poultry Poultry Diseases

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• Source:
  Emerg Infect Dis. 22(4):598-607.
• Pubmed ID:
  26982379
• Pubmed Central ID:
  PMC4806937
• Document Type:
  Journal Article
• Place as Subject:
  China
• Volume:
  22
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:039116da8212270b9605d4497a786a4d71b1912ddc4d52cfa5c57a64f518e85c
• Download URL:
  https://stacks.cdc.gov/view/cdc/38722/cdc_38722_DS1.pdf
• File Type:
  [PDF - 848.09 KB ]