Details:

Alternative Title:
Sci Total Environ
Publisher's site:
http://dx.doi.org/10.1016/j.scitotenv.2015.09.084
Personal Author:
Bowler, Rosemarie M. ; Beseler, Cheryl L. ; Gocheva, Vihra V. ; Colledge, Michelle ; Kornblith, Erica S. ; ... More +
Bowler, Rosemarie M. ; Beseler, Cheryl L. ; Gocheva, Vihra V. ; Colledge, Michelle ; Kornblith, Erica S. ; Julian, Jaime R. ; Kim, Yangho ; Bollweg, George ; Lobdell, Danelle T. Less -
Description:
Background

Manganese (Mn) inhalation has been associated with neuropsychological and neurological sequelae in exposed workers. Few environmental epidemiologic studies have examined the potentially neurotoxic effects of Mn exposure in ambient air on motor function and hand tremor in adult community residents. Mn exposed residents were recruited in two Ohio towns: Marietta, a town near a ferro-manganese smelter, and East Liverpool, a town adjacent to a facility processing, crushing, screening, and packaging Mn products.

Methods

Chronic (≥10 years) exposure to ambient air Mn in adult residents and effects on neuropsychological and neurological outcomes were investigated. Participants from Marietta (n = 100) and East Liverpool (n = 86) were combined for analyses. AERMOD dispersion modeling of fixed-site outdoor air monitoring data estimated Mn inhalation over a ten year period. Adult Mn-exposed residents’ psychomotor ability was assessed using Finger Tapping, Hand Dynamometer, Grooved Pegboard, and the Computerized Adaptive Testing System (CATSYS) Tremor system. Bayesian structural equation modeling was used to assess associations between air-Mn and motor function and tremor.

Results

Air-Mn exposure was significantly correlated in bivariate analyses with the tremor test (CATSYS) for intensity, center frequency and harmonic index. The Bayesian path analysis model showed associations of air-Mn with the CATSYS non-dominant center frequency and harmonic index; while the Bayesian structural equation model revealed associations between air-Mn and lower Finger Tapping scores. Household income was significantly associated with motor dysfunction but not with tremor.

Conclusion

Tremor and motor function were associated with higher exposure to airborne Mn.


Subject:
[+]
Adult
Air Pollutants
Air Pollution
Article
Bayes Theorem
Humans
Inhalation Exposure
Neuropsychological Tests

Source:
Sci Total Environ. 541:646-654.
Pubmed ID:
26437342
Pubmed Central ID:
PMC4803294
Document Type:
Journal Article
Funding:
R13 OH009344/OH/NIOSH CDC HHS/United States
Place as Subject:
Ohio
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:40a0013a8778566e0218c075503a62b08fa5569d748c96065f917e4f0a15ed97
File Type:

Supporting Files

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