Tuberculosis Caused by Mycobacterium africanum, United States, 2004–2013

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Sharma, Aditya ; Bloss, Emily ; Heilig, Charles M. ; Click, Eleanor S.
• Description:
  Mycobacterium africanum is endemic to West Africa and causes tuberculosis (TB). We reviewed reported cases of TB in the United States during 2004-2013 that had lineage assigned by genotype (spoligotype and mycobacterial interspersed repetitive unit variable number tandem repeats). M. africanum caused 315 (0.4%) of 73,290 TB cases with lineage assigned by genotype. TB caused by M. africanum was associated more with persons from West Africa (adjusted odds ratio [aOR] 253.8, 95% CI 59.9-1,076.1) and US-born black persons (aOR 5.7, 95% CI 1.2-25.9) than with US-born white persons. TB caused by M. africanum did not show differences in clinical characteristics when compared with TB caused by M. tuberculosis. Clustered cases defined as >2 cases in a county with identical 24-locus mycobacterial interspersed repetitive unit genotypes, were less likely for M. africanum (aOR 0.1, 95% CI 0.1-0.4), which suggests that M. africanum is not commonly transmitted in the United States.
• Subjects:
  Genotype Humans Mycobacterium/genetics Mycobacterium Tuberculosis/genetics Species Specificity Synopsis Tuberculosis/epidemiology Tuberculosis/microbiology Tuberculosis/transmission
• Source:
  Emerg Infect Dis. 22(3):396-403.
• Pubmed ID:
  26886258
• Pubmed Central ID:
  PMC4766873
• Document Type:
  Journal Article
• Place as Subject:
  Africa, Western ; United States
• Location:
  Africa ; North America
• Volume:
  22
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e1f4d1078526f9bf68b34dcdb9d54ccc2c6501d626edd368bb7b3d5e4b6706da
• Download URL:
  https://stacks.cdc.gov/view/cdc/38462/cdc_38462_DS1.pdf
• File Type:
  [PDF - 618.31 KB ]