i
Persistent hypogonadotropic hypogonadism in men after severe traumatic brain injury: temporal hormone profiles and outcome prediction
-
2016 Jul-Aug
-
-
Source: J Head Trauma Rehabil. 31(4):277-287.
[PDF-588.98 KB]
Details:
-
Alternative Title:J Head Trauma Rehabil
-
Personal Author:
-
Description:Objective
(1) Examine relationships between persistent hypogonadotropic hypogonadism (PHH) and long-term outcomes after severe traumatic brain injury (TBI); (2) determine if sub-acute testosterone levels can predict PHH.
Setting
Level 1 trauma center at a university hospital.
Participants
Consecutive sample of men with severe TBI between 2004 and 2009.
Design
Prospective cohort study.
Main Measures
Post-TBI blood samples were collected during week 1, every 2 weeks until 26 weeks, and at 52 weeks. Serum hormone levels were measured, and individuals were designated as having PHH if ≥50% of samples met criteria for hypogonadotropic hypogonadism. At 6 and 12 months post-injury, we assessed global outcome, disability, functional cognition, depression, and quality-of-life.
Results
We recruited 78 men; median (IQR) age was 28.5 (22–42) years. 34 patients (44%) had PHH during the first year post-injury. Multivariable regression, controlling for age, demonstrated PHH status predicted worse global outcome scores, more disability, and reduced functional cognition at 6 and 12 months post-TBI. Two-step testosterone screening for PHH at 12–16 weeks post-injury yielded a sensitivity of 79% and specificity of 100%.
Conclusion
PHH status in men predicts poor outcome after severe TBI, and PHH can accurately be predicted at 12–16 weeks.
-
Subjects:
-
Source:
-
Pubmed ID:26360007
-
Pubmed Central ID:PMC4786474
-
Document Type:
-
Funding:
-
Volume:31
-
Issue:4
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
