Human Papillomavirus Genotype and Oropharynx Cancer Survival in the United States

Details

• Alternative Title:
  Eur J Cancer
• Personal Author:
  Goodman, Marc T. ; Saraiya, Mona ; Thompson, Trevor D. ; Steinau, Martin ; Hernandez, Brenda Y. ; Lynch, Charles F. ; Lyu, Christopher W. ; Wilkinson, Edward J. ; Tucker, Thomas ; Copeland, Glenn ; Peters, Edward S. ; Altekruse, Sean ; Unger, Elizabeth R.
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• Description:
  Background ; The presence of human papillomavirus (HPV) DNA in oropharyngeal squamous cell cancer (OPSCC) tissue appears to be a strong predictor of improved prognosis, but this observation has not been explored in a population-based sample with generalizable findings. ; Methods ; Follow-up data from a large sample of OPSCC patients identified through six population-based cancer registries in the US was used to characterize the association of tumor HPV status with survival. ; Results ; HPV DNA was detected in tumor tissue from 71% (378/529) of the OPSCC patients. A total of 65% of patients with HPV16-associated tumors survived 5-years compared to 46% of patients with other HPV-types and 28% of patients with HPV-negative tumors (p log-rank test <0.0001). The OPSCC patients with detectable HPV16 DNA had a 62% reduced hazard of death at 5-years, and patients with other HPV types had a 42% reduced hazard of death at 5-years compared to HPV-negative patients. Compared to non-Hispanic Whites, Blacks with OPSCC had a 2.5-fold greater risk of death at 5-years after adjustment for HPV-status and other prognostic variables. Both surgery and radiation therapy were associated with a reduced 5-year risk of death, but no evidence was found for an interaction between HPV-status and radiotherapy or surgery on survival time. ; Conclusions ; Data from this US study suggest that HPV16-positive OPSCC patients survive longer than HPV-negative patients regardless of treatment, highlighting the prognostic importance of HPV-status for this malignancy. Optimal treatment regimens for OPSCC could be tailored to each patient’s HPV-status and prognostic profile.malignancy.
• Keywords:
  • Cancer of the oropharynx
  • human papillomavirus
  • archived tissue
  • cancer registry
  • survival
  • Aged
  • Carcinoma, Squamous Cell
  • DNA, Viral
  • Female
  • Genotype
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• Source:
  Eur J Cancer. 51(18):2759-2767
• Pubmed ID:
  26602016
• Pubmed Central ID:
  PMC4666760
• Document Type:
  Journal Article
• Funding:
  R01 CA077318/CA/NCI NIH HHSUnited States/ ; U58 DP000810/DP/NCCDPHP CDC HHSUnited States/ ; N01-PC-35137/PC/NCI NIH HHSUnited States/ ; 5U58DP000810-5/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA177558/CA/NCI NIH HHSUnited States/ ; 5U58DP000812-5/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA071789/CA/NCI NIH HHSUnited States/ ; N01 PC035137/PC/NCI NIH HHSUnited States/ ; U58 DP000769/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35143/CA/NCI NIH HHSUnited States/ ; P30 CA086862/CA/NCI NIH HHSUnited States/ ; U58 DP000844/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35137/CA/NCI NIH HHSUnited States/ ; 5U58DP000769-5/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000812/DP/NCCDPHP CDC HHSUnited States/ ; ImNIH/Intramural NIH HHSUnited States/ ; N01-PC-35143/PC/NCI NIH HHSUnited States/ ; 5U58DP000844-5/DP/NCCDPHP CDC HHSUnited States/
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• Volume:
  51
• Issue:
  18
• Download URL:
  https://stacks.cdc.gov/view/cdc/38350/cdc_38350_DS1.pdf
• File Type:
  [PDF - 366.11 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d20120eb52dc56db9b376a718376ff13452a30b8661ae49f2fba380efefd045a