Human Papillomavirus Genotype and Oropharynx Cancer Survival in the United States

Goodman, Marc T.; Saraiya, Mona; Thompson, Trevor D.; Steinau, Martin; Hernandez, Brenda Y.; Lynch, Charles F.; Lyu, Christopher W.; Wilkinson, Edward J.; Tucker, Thomas; Copeland, Glenn; Peters, Edward S.; Altekruse, Sean; Unger, Elizabeth R.

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Human Papillomavirus Genotype and Oropharynx Cancer Survival in the United States

Published Date:

Nov 18 2015

Source:

Eur J Cancer. 51(18):2759-2767.

[PDF-366.11 KB]

Details:

Personal Authors:

Goodman, Marc T. ; Saraiya, Mona ; Thompson, Trevor D. ; Steinau, Martin ; Hernandez, Brenda Y. ; ... More ▼

Keywords:

[+]

Pubmed ID:

26602016

Pubmed Central ID:

PMC4666760

Description:

Background

The presence of human papillomavirus (HPV) DNA in oropharyngeal squamous cell cancer (OPSCC) tissue appears to be a strong predictor of improved prognosis, but this observation has not been explored in a population-based sample with generalizable findings.

Methods

Follow-up data from a large sample of OPSCC patients identified through six population-based cancer registries in the US was used to characterize the association of tumor HPV status with survival.

Results

HPV DNA was detected in tumor tissue from 71% (378/529) of the OPSCC patients. A total of 65% of patients with HPV16-associated tumors survived 5-years compared to 46% of patients with other HPV-types and 28% of patients with HPV-negative tumors (p log-rank test <0.0001). The OPSCC patients with detectable HPV16 DNA had a 62% reduced hazard of death at 5-years, and patients with other HPV types had a 42% reduced hazard of death at 5-years compared to HPV-negative patients. Compared to non-Hispanic Whites, Blacks with OPSCC had a 2.5-fold greater risk of death at 5-years after adjustment for HPV-status and other prognostic variables. Both surgery and radiation therapy were associated with a reduced 5-year risk of death, but no evidence was found for an interaction between HPV-status and radiotherapy or surgery on survival time.

Conclusions

Data from this US study suggest that HPV16-positive OPSCC patients survive longer than HPV-negative patients regardless of treatment, highlighting the prognostic importance of HPV-status for this malignancy. Optimal treatment regimens for OPSCC could be tailored to each patient’s HPV-status and prognostic profile.malignancy.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

U58 DP000769/DP/NCCDPHP CDC HHS/United States
N01PC35143/CA/NCI NIH HHS/United States
R01 CA077318/CA/NCI NIH HHS/United States
N01-PC-35137/PC/NCI NIH HHS/United States
P30 CA086862/CA/NCI NIH HHS/United States
U58 DP000844/DP/NCCDPHP CDC HHS/United States
N01PC35137/CA/NCI NIH HHS/United States
5U58DP000769-5/DP/NCCDPHP CDC HHS/United States
5U58DP000810-5/DP/NCCDPHP CDC HHS/United States
Intramural NIH HHS/United States
U58 DP000812/DP/NCCDPHP CDC HHS/United States
5U58DP000812-5/DP/NCCDPHP CDC HHS/United States
P30 CA071789/CA/NCI NIH HHS/United States
N01-PC-35143/PC/NCI NIH HHS/United States
5U58DP000844-5/DP/NCCDPHP CDC HHS/United States
N01 PC035137/PC/NCI NIH HHS/United States

Supporting Files:

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	NIHMS731417-supplement-2.xlsx	application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
	nihms731417.nxml	text/xml
	nihms731417f1.gif	image/gif
	nihms731417f1.jpg	image/jpeg

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