Details:

Alternative Title:
Eur J Cancer
Personal Author:
Goodman, Marc T. ; Saraiya, Mona ; Thompson, Trevor D. ; Steinau, Martin ; Hernandez, Brenda Y. ; ... More +
Goodman, Marc T. ; Saraiya, Mona ; Thompson, Trevor D. ; Steinau, Martin ; Hernandez, Brenda Y. ; Lynch, Charles F. ; Lyu, Christopher W. ; Wilkinson, Edward J. ; Tucker, Thomas ; Copeland, Glenn ; Peters, Edward S. ; Altekruse, Sean ; Unger, Elizabeth R. Less -
Description:
Background

The presence of human papillomavirus (HPV) DNA in oropharyngeal squamous cell cancer (OPSCC) tissue appears to be a strong predictor of improved prognosis, but this observation has not been explored in a population-based sample with generalizable findings.

Methods

Follow-up data from a large sample of OPSCC patients identified through six population-based cancer registries in the US was used to characterize the association of tumor HPV status with survival.

Results

HPV DNA was detected in tumor tissue from 71% (378/529) of the OPSCC patients. A total of 65% of patients with HPV16-associated tumors survived 5-years compared to 46% of patients with other HPV-types and 28% of patients with HPV-negative tumors (p log-rank test <0.0001). The OPSCC patients with detectable HPV16 DNA had a 62% reduced hazard of death at 5-years, and patients with other HPV types had a 42% reduced hazard of death at 5-years compared to HPV-negative patients. Compared to non-Hispanic Whites, Blacks with OPSCC had a 2.5-fold greater risk of death at 5-years after adjustment for HPV-status and other prognostic variables. Both surgery and radiation therapy were associated with a reduced 5-year risk of death, but no evidence was found for an interaction between HPV-status and radiotherapy or surgery on survival time.

Conclusions

Data from this US study suggest that HPV16-positive OPSCC patients survive longer than HPV-negative patients regardless of treatment, highlighting the prognostic importance of HPV-status for this malignancy. Optimal treatment regimens for OPSCC could be tailored to each patient’s HPV-status and prognostic profile.malignancy.


Subject:
[+]
Aged
Carcinoma, Squamous Cell
DNA, Viral
Female
Genotype
Head And Neck Neoplasms
Human Papillomavirus DNA Tests
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Oropharyngeal Neoplasms
Papillomaviridae
Papillomavirus Infections
Proportional Hazards Models
Racial Groups
Risk Factors
SEER Program
Time Factors
Treatment Outcome

Source:
Eur J Cancer. 51(18):2759-2767.
Pubmed ID:
26602016
Pubmed Central ID:
PMC4666760
Document Type:
Journal Article
Funding:
U58 DP000769/DP/NCCDPHP CDC HHS/United States ; N01PC35143/CA/NCI NIH HHS/United States ; R01 CA077318/CA/NCI NIH HHS/United States ; N01-PC-35137/PC/NCI NIH HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; ... More +
U58 DP000769/DP/NCCDPHP CDC HHS/United States ; N01PC35143/CA/NCI NIH HHS/United States ; R01 CA077318/CA/NCI NIH HHS/United States ; N01-PC-35137/PC/NCI NIH HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; U58 DP000844/DP/NCCDPHP CDC HHS/United States ; N01PC35137/CA/NCI NIH HHS/United States ; 5U58DP000769-5/DP/NCCDPHP CDC HHS/United States ; 5U58DP000810-5/DP/NCCDPHP CDC HHS/United States ; Intramural NIH HHS/United States ; U58 DP000812/DP/NCCDPHP CDC HHS/United States ; 5U58DP000812-5/DP/NCCDPHP CDC HHS/United States ; P30 CA071789/CA/NCI NIH HHS/United States ; N01-PC-35143/PC/NCI NIH HHS/United States ; 5U58DP000844-5/DP/NCCDPHP CDC HHS/United States ; N01 PC035137/PC/NCI NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:d20120eb52dc56db9b376a718376ff13452a30b8661ae49f2fba380efefd045a
File Type:

Supporting Files

• 	NIHMS731417-supplement-1.docx	docx
  	NIHMS731417-supplement-2.xlsx	xlsx
  	nihms731417.nxml	xml
  	nihms731417f1.gif	gif
  	nihms731417f1.jpg	jpeg

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