Human Papillomavirus Genotype and Oropharynx Cancer Survival in the United States

Goodman, Marc T.; Saraiya, Mona; Thompson, Trevor D.; Steinau, Martin; Hernandez, Brenda Y.; Lynch, Charles F.; Lyu, Christopher W.; Wilkinson, Edward J.; Tucker, Thomas; Copeland, Glenn; Peters, Edward S.; Altekruse, Sean; Unger, Elizabeth R.

doi:10.1016/j.ejca.2015.09.005

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Human Papillomavirus Genotype and Oropharynx Cancer Survival in the United States

Published Date:

Nov 18 2015

Publisher's site:

http://dx.doi.org/10.1016/j.ejca.2015.09.005 New Site Icon

Source:

Eur J Cancer. 51(18):2759-2767.

[PDF - 366.11 KB]

Details:

Personal Authors:

Goodman, Marc T. ; Saraiya, Mona ; Thompson, Trevor D. ; Steinau, Martin ; Hernandez, Brenda Y. ; ... More ▼

Keywords:

[+]

Pubmed ID:

26602016

Pubmed Central ID:

PMC4666760

Description:

Background

The presence of human papillomavirus (HPV) DNA in oropharyngeal squamous cell cancer (OPSCC) tissue appears to be a strong predictor of improved prognosis, but this observation has not been explored in a population-based sample with generalizable findings.

Methods

Follow-up data from a large sample of OPSCC patients identified through six population-based cancer registries in the US was used to characterize the association of tumor HPV status with survival.

Results

HPV DNA was detected in tumor tissue from 71% (378/529) of the OPSCC patients. A total of 65% of patients with HPV16-associated tumors survived 5-years compared to 46% of patients with other HPV-types and 28% of patients with HPV-negative tumors (p log-rank test <0.0001). The OPSCC patients with detectable HPV16 DNA had a 62% reduced hazard of death at 5-years, and patients with other HPV types had a 42% reduced hazard of death at 5-years compared to HPV-negative patients. Compared to non-Hispanic Whites, Blacks with OPSCC had a 2.5-fold greater risk of death at 5-years after adjustment for HPV-status and other prognostic variables. Both surgery and radiation therapy were associated with a reduced 5-year risk of death, but no evidence was found for an interaction between HPV-status and radiotherapy or surgery on survival time.

Conclusions

Data from this US study suggest that HPV16-positive OPSCC patients survive longer than HPV-negative patients regardless of treatment, highlighting the prognostic importance of HPV-status for this malignancy. Optimal treatment regimens for OPSCC could be tailored to each patient’s HPV-status and prognostic profile.malignancy.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

U58 DP000769/DP/NCCDPHP CDC HHS/United States
R01 CA077318/CA/NCI NIH HHS/United States
U58 DP000810/DP/NCCDPHP CDC HHS/United States
N01-PC-35137/PC/NCI NIH HHS/United States
U58 DP000844/DP/NCCDPHP CDC HHS/United States
5U58DP000769-5/DP/NCCDPHP CDC HHS/United States
5U58DP000810-5/DP/NCCDPHP CDC HHS/United States
Intramural NIH HHS/United States
N01-PC-35143/CA/NCI NIH HHS/United States
U58 DP000812/DP/NCCDPHP CDC HHS/United States
5U58DP000812-5/DP/NCCDPHP CDC HHS/United States
N01-PC-35137/CA/NCI NIH HHS/United States
P30 CA071789/CA/NCI NIH HHS/United States
N01-PC-35143/PC/NCI NIH HHS/United States
5U58DP000844-5/DP/NCCDPHP CDC HHS/United States
N01 PC035137/PC/NCI NIH HHS/United States

Supporting Files:

NIHMS731417-supplement-1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
NIHMS731417-supplement-2.xlsx	application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
nihms731417.nxml	application/octet-stream
nihms731417f1.gif	image/gif
nihms731417f1.jpg	image/jpeg

No Related Documents.

You May Also Like:

Human Papillomavirus Prevalence in Invasive Laryngeal Cancer in the United States

Personal Author:

Hernandez, Brenda Y.; Goodman, Marc T.; Lynch, Charles F.; Cozen, Wendy; Unger, Elizabeth R.; Steinau, Martin; Thompson, Trevor; Saber, Maria Sibug; Altekruse, Sean F.; Lyu, Christopher; Saraiya, Mona;

Corporate Author:

The HPV Typing of Cancer Workgroup

Published:

Dec 29 2014

Source:

PLoS One. 2014; 9(12).

Description:

Purpose : Human papillomavirus (HPV) is a major risk factor for specific cancers of the head and neck, particularly malignancies of the tonsil and base of the tongue. However, the role of HPV in the development of laryngeal cancer has not been defini...

File Type:

[PDF - 313.37 KB]
Human Papillomavirus Genotype Prevalence in Invasive Penile Cancers from a Registry-Based United States Population

Personal Author:

Hernandez, Brenda Y.; Goodman, Marc T.; Unger, Elizabeth R.; Steinau, Martin; Powers, Amy; Lynch, Charles F.; Cozen, Wendy; Saber, Maria Sibug; Peters, Edward S.; Wilkinson, Edward J.; Copeland, Glenn; Hopenhayn, Claudia; Huang, Youjie; Watson, Meg; Altekruse, Sean F.; Lyu, Christopher; Saraiya, Mona;

Corporate Author:

The HPV Typing of Cancer Workgroup

Published:

Feb 05 2014

Source:

Front Oncol. 2014; 4.

Description:

Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited.|HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patient...

File Type:

[PDF - 534.13 KB]
Human Papillomavirus Prevalence in Oropharyngeal Cancer before Vaccine Introduction, United States

Personal Author:

Steinau, Martin; Saraiya, Mona; Goodman, Marc T.; Peters, Edward S.; Watson, Meg; Cleveland, Jennifer L.; Lynch, Charles F.; Wilkinson, Edward J.; Hernandez, Brenda Y.; Copeland, Glen; Saber, Maria S.; Hopenhayn, Claudia; Huang, Youjie; Cozen, Wendy; Lyu, Christopher; Unger, Elizabeth R.;

Corporate Author:

HPV Typing of Cancers Workgroup

Published:

May 2014

Source:

Emerg Infect Dis. 20(5):822-828.

Description:

We conducted a study to determine prevalence of HPV types in oropharyngeal cancers in the United States and establish a prevaccine baseline for monitoring the impact of vaccination. HPV DNA was extracted from tumor tissue samples from patients in who...

File Type:

[PDF - 957.79 KB]
Cost-effectiveness of Human Papillomavirus Vaccination in the United States

Personal Author:

Chesson, Harrell W.; Ekwueme, Donatus U.; Saraiya, Mona; Markowitz, Lauri E.;

Published:

Feb 2008

Source:

Emerg Infect Dis. 14(2):244-251.

Description:

We describe a simplified model, based on the current economic and health effects of human papillomavirus (HPV), to estimate the cost-effectiveness of HPV vaccination of 12-year-old girls in the United States. Under base-case parameter values, the est...

File Type:

[PDF - 365.12 KB]
Human Papillomavirus Genotype Prevalence in Invasive Vaginal Cancer from a Registry-Based Population

Personal Author:

Sinno, Abdulrahman K.; Saraiya, Mona; Thompson, Trevor D; Hernandez, Brenda Y.; Goodman, Marc T.; Steinau, Martin; Lynch, Charles F.; Cozen, Wendy; Saber, Maria Sibug; Peters, Edward S.; Wilkinson, Edward J.; Copeland, Glenn; Hopenhayn, Claudia; Watson, Meg; Lyu, Christopher; Unger, Elizabeth R.;

Published:

Apr 2014

Source:

Obstet Gynecol. 123(4):817-821.

Description:

Objective : To describe the human papillomavirus (HPV) genotype distribution in invasive vaginal cancers diagnosed prior to the introduction of the HPV vaccine, and evaluate if survival differed by HPV status. : Methods : Four population-based regist...

File Type:

[PDF - 305.90 KB]