Human Papillomavirus Genotype and Oropharynx Cancer Survival in the United States

Details

• Alternative Title:
  Eur J Cancer
• Personal Author:
  Goodman, Marc T. ; Saraiya, Mona ; Thompson, Trevor D. ; Steinau, Martin ; Hernandez, Brenda Y. ; Lynch, Charles F. ; Lyu, Christopher W. ; Wilkinson, Edward J. ; Tucker, Thomas ; Copeland, Glenn ; Peters, Edward S. ; Altekruse, Sean ; Unger, Elizabeth R.
• Description:
  Background
  
  The presence of human papillomavirus (HPV) DNA in oropharyngeal squamous cell cancer (OPSCC) tissue appears to be a strong predictor of improved prognosis, but this observation has not been explored in a population-based sample with generalizable findings.
  
  Methods
  
  Follow-up data from a large sample of OPSCC patients identified through six population-based cancer registries in the US was used to characterize the association of tumor HPV status with survival.
  
  Results
  
  HPV DNA was detected in tumor tissue from 71% (378/529) of the OPSCC patients. A total of 65% of patients with HPV16-associated tumors survived 5-years compared to 46% of patients with other HPV-types and 28% of patients with HPV-negative tumors (p log-rank test <0.0001). The OPSCC patients with detectable HPV16 DNA had a 62% reduced hazard of death at 5-years, and patients with other HPV types had a 42% reduced hazard of death at 5-years compared to HPV-negative patients. Compared to non-Hispanic Whites, Blacks with OPSCC had a 2.5-fold greater risk of death at 5-years after adjustment for HPV-status and other prognostic variables. Both surgery and radiation therapy were associated with a reduced 5-year risk of death, but no evidence was found for an interaction between HPV-status and radiotherapy or surgery on survival time.
  
  Conclusions
  
  Data from this US study suggest that HPV16-positive OPSCC patients survive longer than HPV-negative patients regardless of treatment, highlighting the prognostic importance of HPV-status for this malignancy. Optimal treatment regimens for OPSCC could be tailored to each patient’s HPV-status and prognostic profile.malignancy.
  
  
• Keywords:
  Aged Archived Tissue Cancer Of The Oropharynx Cancer Registry Carcinoma, Squamous Cell DNA, Viral Female Genotype Head And Neck Neoplasms Human Papillomavirus Human Papillomavirus DNA Tests Humans Kaplan-Meier Estimate Male Middle Aged Oropharyngeal Neoplasms Papillomaviridae Papillomavirus Infections Proportional Hazards Models Racial Groups Risk Factors SEER Program Squamous Cell Carcinoma Of Head And Neck Survival Time Factors Treatment Outcome United States

  More +
• Source:
  Eur J Cancer. 51(18):2759-2767
• Pubmed ID:
  26602016
• Pubmed Central ID:
  PMC4666760
• Document Type:
  Journal Article
• Funding:
  R01 CA077318/CA/NCI NIH HHSUnited States/ ; U58 DP000810/DP/NCCDPHP CDC HHSUnited States/ ; N01-PC-35137/PC/NCI NIH HHSUnited States/ ; 5U58DP000810-5/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA177558/CA/NCI NIH HHSUnited States/ ; 5U58DP000812-5/DP/NCCDPHP CDC HHSUnited States/ ; P30 CA071789/CA/NCI NIH HHSUnited States/ ; N01 PC035137/PC/NCI NIH HHSUnited States/ ; U58 DP000769/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35143/CA/NCI NIH HHSUnited States/ ; P30 CA086862/CA/NCI NIH HHSUnited States/ ; U58 DP000844/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35137/CA/NCI NIH HHSUnited States/ ; 5U58DP000769-5/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000812/DP/NCCDPHP CDC HHSUnited States/ ; ImNIH/Intramural NIH HHSUnited States/ ; N01-PC-35143/PC/NCI NIH HHSUnited States/ ; 5U58DP000844-5/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  51
• Issue:
  18
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d20120eb52dc56db9b376a718376ff13452a30b8661ae49f2fba380efefd045a
• Download URL:
  https://stacks.cdc.gov/view/cdc/38350/cdc_38350_DS1.pdf
• File Type:
  [PDF - 366.11 KB ]