Maternal Tenofovir Disoproxil Fumarate Use in Pregnancy and Growth Outcomes among HIV-Exposed Uninfected Infants in Kenya
Published Date:Dec 28 2015
Source:Infect Dis Obstet Gynecol. 2015; 2015.
CD4 Lymphocyte Count
Infectious Disease Transmission, Vertical
Pregnancy Complications, Infectious
Pubmed Central ID:PMC4707364
Funding:T32AI007140/AI/NIAID NIH HHS/United States
U2G PS002047/PS/NCHHSTP CDC HHS/United States
T32 AI007140/AI/NIAID NIH HHS/United States
U2GPS002047/PHS HHS/United States
K24 HD054314/HD/NICHD NIH HHS/United States
T32AI07140/AI/NIAID NIH HHS/United States
P30 AI027757/AI/NIAID NIH HHS/United States
Description:Tenofovir disoproxil fumarate (TDF) is commonly used in antiretroviral treatment (ART) and preexposure prophylaxis regimens. We evaluated the relationship of prenatal TDF use and growth outcomes among Kenyan HIV-exposed uninfected (HEU) infants.|We included PCR-confirmed HEU infants enrolled in a cross-sectional survey of mother-infant pairs conducted between July and December 2013 in Kenya. Maternal ART regimen during pregnancy was determined by self-report and clinic records. Six-week and 9-month z-scores for weight-for-age (WAZ), weight-for-length (WLZ), length-for-age (LAZ), and head circumference-for-age (HCAZ) were compared among HEU infants with and without TDF exposure using t-tests and multivariate linear regression models.|Among 277 mothers who received ART during pregnancy, 63% initiated ART before pregnancy, of which 89 (32%) used TDF. No differences in birth weight (3.0 kg versus 3.1 kg, p = 0.21) or gestational age (38 weeks versus 38 weeks, p = 0.16) were detected between TDF-exposed and TDF-unexposed infants. At 6 weeks, unadjusted mean WAZ was lower among TDF-exposed infants (-0.8 versus -0.4, p = 0.03), with a trend towards association in adjusted analyses (p = 0.06). There were no associations between prenatal TDF use and WLZ, LAZ, and HCAZ in 6-week or 9-month infant cohorts.|Maternal TDF use did not adversely affect infant growth compared to other regimens.
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