Maternal Tenofovir Disoproxil Fumarate Use in Pregnancy and Growth Outcomes among HIV-Exposed Uninfected Infants in Kenya

Details

• Alternative Title:
  Infect Dis Obstet Gynecol
• Personal Author:
  Pintye, Jillian ; Langat, Agnes ; Singa, Benson ; Kinuthia, John ; Odeny, Beryne ; Katana, Abraham ; Nganga, Lucy ; John-Stewart, Grace ; McGrath, Christine J.
• Description:
  Tenofovir disoproxil fumarate (TDF) is commonly used in antiretroviral treatment (ART) and preexposure prophylaxis regimens. We evaluated the relationship of prenatal TDF use and growth outcomes among Kenyan HIV-exposed uninfected (HEU) infants.|We included PCR-confirmed HEU infants enrolled in a cross-sectional survey of mother-infant pairs conducted between July and December 2013 in Kenya. Maternal ART regimen during pregnancy was determined by self-report and clinic records. Six-week and 9-month z-scores for weight-for-age (WAZ), weight-for-length (WLZ), length-for-age (LAZ), and head circumference-for-age (HCAZ) were compared among HEU infants with and without TDF exposure using t-tests and multivariate linear regression models.|Among 277 mothers who received ART during pregnancy, 63% initiated ART before pregnancy, of which 89 (32%) used TDF. No differences in birth weight (3.0 kg versus 3.1 kg, p = 0.21) or gestational age (38 weeks versus 38 weeks, p = 0.16) were detected between TDF-exposed and TDF-unexposed infants. At 6 weeks, unadjusted mean WAZ was lower among TDF-exposed infants (-0.8 versus -0.4, p = 0.03), with a trend towards association in adjusted analyses (p = 0.06). There were no associations between prenatal TDF use and WLZ, LAZ, and HCAZ in 6-week or 9-month infant cohorts.|Maternal TDF use did not adversely affect infant growth compared to other regimens.
• Subjects:
  Adult Anti-HIV Agents Antibiotic Prophylaxis Birth Weight CD4 Lymphocyte Count Female HIV Infections Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical Pregnancy Pregnancy Complications, Infectious Pregnancy Outcome Research Article Retrospective Studies Tenofovir Young Adult

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• Source:
  Infect Dis Obstet Gynecol. 2015; 2015.
• Pubmed ID:
  26823647
• Pubmed Central ID:
  PMC4707364
• Document Type:
  Journal Article
• Funding:
  T32AI007140/AI/NIAID NIH HHS/United States ; U2G PS002047/PS/NCHHSTP CDC HHS/United States ; T32 AI007140/AI/NIAID NIH HHS/United States ; U2GPS002047/PHS HHS/United States ; K24 HD054314/HD/NICHD NIH HHS/United States ; T32AI07140/AI/NIAID NIH HHS/United States ; P30 AI027757/AI/NIAID NIH HHS/United States ; PEPFAR/United States
• Name as Subject:
  United States. President's Emergency Plan For AIDS Relief (PEPFAR)
• Place as Subject:
  Kenya
• Volume:
  2015
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:6124d3bfe249374e8d19076fa953425224d3b395d976f1f93546cd317940bdf197d00d350897f0d40c071c24ae40b772afaa937de4da0518301ec139d1575933
• Download URL:
  https://stacks.cdc.gov/view/cdc/38125/cdc_38125_DS1.pdf
• File Type:
  [PDF - 546.78 KB ]