Dysmobility syndrome and mortality risk in US men and women age 50 years and older1

Details

• Alternative Title:
  Osteoporos Int
• Personal Author:
  Looker, Anne C.
• Description:
  Purpose
  
  Dysmobility syndrome was recently proposed as an approach to evaluate the musculoskeletal health of older persons, but data linking this syndrome to adverse outcomes are currently lacking. The present study used data from the National Health and Nutrition Examination Survey (NHANES)1999–2002 to assess the relationship between dysmobility and mortality in adults age 50 and older by age, sex, and race or ethnicity.
  
  Methods
  
  Dysmobility was defined as three or more of the following: high body fat, osteoporosis, low muscle mass, low muscle strength, slow gait speed, or falling risk. Body composition and bone density were assessed with dual energy x-ray absorptiometry. Gait speed was measured via a timed walk, muscle strength via isokinetic knee extension, and fall risk via self-reported balance problems in the past year. Hazards ratios (HR) for mortality were calculated with Cox proportional hazards models.
  
  Results
  
  Twenty-two percent of adults age 50+ years had dysmobility in 1999–2002. Mortality risk by dysmobility varied significantly by age (pinteraction=0.001). HRs for those aged 50–69 years were 3.63 (95% CI 2.69, 4.90) and 2.59 (95% CI 1.82, 3.69), respectively, before and after adjusting for all confounders, compared with 1.46 (95% CI 1.07, 1.99) and 1.23 (95% CI 0.89, 1.69) for those aged 70+ years. The relationship was significant when examined by sex or race/ethnicity within age group for most subgroups.
  
  Conclusions
  
  Dysmobility was associated with increased mortality risk in adults age 50 years and older, with risk being higher in those age 50–69 years than in those age 70+ years.
  
  
• Subjects:
  Absorptiometry, Photon Aged Aged, 80 And Over Age Distribution Bone Density Female Gait Humans Longitudinal Studies Male Middle Aged Mobility Limitation Muscle Strength Nutrition Surveys Osteoporosis Risk Assessment Syndrome

  More +
• Source:
  Osteoporos Int. 26(1):93-102.
• Pubmed ID:
  25297891
• Pubmed Central ID:
  PMC4757903
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Name as Subject:
  National Health and Nutrition Examination Survey (U.S.)
• Place as Subject:
  United States
• Volume:
  26
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a26b18632cf1fa84daea71dc8c8c2a9ab8a88d4d7e2935f19f6984b7a3667ece
• Download URL:
  https://stacks.cdc.gov/view/cdc/38081/cdc_38081_DS1.pdf
• File Type:
  [PDF - 545.62 KB ]