Details:

Alternative Title:
J Clin Densitom
Personal Author:
Bhattacharya, Amit ; Watts, Nelson B. ; Dwivedi, Alok ; Shukla, Rakesh ; Mani, Ashutosh ; ... More +
Bhattacharya, Amit ; Watts, Nelson B. ; Dwivedi, Alok ; Shukla, Rakesh ; Mani, Ashutosh ; Diab, Dima Less -
Description:
We evaluated functional measures of neuromuscular integrity and bone's resistance to fracture as a combined tool in discriminating osteoporosis patients with and without fractures. Functional aspects of neuromuscular integrity were quantified with a noninvasive measure of static and dynamic functional postural stability (FPS), and fracture resistance was obtained with bone shock absorption in patients with osteoporosis aged 65-85 and compared our measures with dual-energy X-ray absorptiometry and Fracture Risk Assessment Tool (FRAX [World Health Organization Collaborating Center for Metabolic Bone Diseases, Sheffield, UK]) in women with osteoporosis, some with and some without vertebral fractures. Patients with vertebral fracture showed larger static FPS (postural sway excursion) in the mediolateral and anterior-posterior directions, suggesting poorer balance. Most of the variables of dynamic FPS showed significant differences between fracture and no-fracture groups (e.g., the fracture group took significantly longer during turning, implying poorer dynamic balance control). Also, compared with healthy control subjects, all 4 dynamic FPS responses for osteoporosis patients with and without fracture were significantly poorer, suggesting potential risk for falls. In summary, patients with osteoporosis who have vertebral fractures (compared with patients with similarly low bone mineral density and other nonfracture risk fractures) have not only lower bone shock absorption damping (ζ) but also increased postural imbalance.
Subject:
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Absorptiometry, Photon
Accidental Falls
Aged
Aged, 80 And Over
Bone Density
Female
Humans
Male
Neuromuscular Junction
Osteoporosis
Osteoporotic Fractures
Postural Balance
Risk Assessment
Risk Factors
Spinal Fractures

Source:
J Clin Densitom. 19(2):154-164
Pubmed ID:
25936482
Pubmed Central ID:
PMC6894175
Document Type:
Journal Article
Funding:
T42 OH008432/OH/NIOSH CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:66670ba0e333ca28f6e4478ccee28ada857d6966abbd22da58e50335c33d26e0
File Type:

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