Prognostic Indicators for Ebola Patient Survival

Crowe, Samuel J.; Maenner, Matthew J.; Kuah, Solomon; Erickson, Bobbie Rae; Coffee, Megan; Knust, Barbara; Klena, John; Foday, Joyce; Hertz, Darren; Hermans, Veerle; Achar, Jay; Caleo, Grazia M.; Van Herp, Michel; Albariño, César G.; Amman, Brian; Basile, Alison Jane; Bearden, Scott; Belser, Jessica A.; Bergeron, Eric; Blau, Dianna; Brault, Aaron C.; Campbell, Shelley; Flint, Mike; Gibbons, Aridth; Goodman, Christin; McMullan, Laura; Paddock, Christopher; Russell, Brandy; Salzer, Johanna S.; Sanchez, Angela; Sealy, Tara; Wang, David; Saffa, Gbessay; Turay, Alhajie; Nichol, Stuart T.; Towner, Jonathan S.

doi:10.3201/eid2202.151250

i

Prognostic Indicators for Ebola Patient Survival

Supporting Files Public Domain

Feb 2016
By Crowe, Samuel J. ; Maenner, Matthew J. ; Kuah, Solomon ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Crowe, Samuel J. ; Maenner, Matthew J. ; Kuah, Solomon ; Erickson, Bobbie Rae ; Coffee, Megan ; Knust, Barbara ; Klena, John ; Foday, Joyce ; Hertz, Darren ; Hermans, Veerle ; Achar, Jay ; Caleo, Grazia M. ; Van Herp, Michel ; Albariño, César G. ; Amman, Brian ; Basile, Alison Jane ; Bearden, Scott ; Belser, Jessica A. ; Bergeron, Eric ; Blau, Dianna ; Brault, Aaron C. ; Campbell, Shelley ; Flint, Mike ; Gibbons, Aridth ; Goodman, Christin ; McMullan, Laura ; Paddock, Christopher ; Russell, Brandy ; Salzer, Johanna S. ; Sanchez, Angela ; Sealy, Tara ; Wang, David ; Saffa, Gbessay ; Turay, Alhajie ; Nichol, Stuart T. ; Towner, Jonathan S.
Description:

To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus-positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus-positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of <24 survived. Ct values may be useful for clinicians making treatment decisions or managing patient or family expectations.
Subjects:

Adolescent Adult Ebolavirus Female Hemorrhagic Fever, Ebola Hospitalization Humans Male Middle Aged Mortality Population Surveillance Prognosis Young Adult
Source:

Emerg Infect Dis. 22(2):217-223.
Pubmed ID:

26812579
Pubmed Central ID:

PMC4734506
Document Type:

Journal Article
Place as Subject:

Sierra Leone
Location:

Africa
Volume:

22
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:37a35307bf83f4d4ef6bd52490eac2a70495f11e782f7009a92045ffd114a1e6
Download URL:

https://stacks.cdc.gov/view/cdc/37996/cdc_37996_DS1.pdf
File Type:

[PDF - 578.37 KB ]

File Language:

English

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