Randomized Controlled Trial of Hospital-Based Hygiene and Water Treatment Intervention (CHoBI7) to Reduce Cholera

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  George, Christine Marie ; Monira, Shirajum ; Sack, David A. ; Rashid, Mahamud-ur ; Saif-Ur-Rahman, K.M. ; Mahmud, Toslim ; Rahman, Zillur ; Mustafiz, Munshi ; Bhuyian, Sazzadul Islam ; Winch, Peter J. ; Leontsini, Elli ; Perin, Jamie ; Begum, Farzana ; Zohura, Fatema ; Biswas, Shwapon ; Parvin, Tahmina ; Zhang, Xiaotong ; Jung, Danielle ; Sack, R. Bradley ; Alam, Munirul
• Description:
  The risk for cholera infection is >100 times higher for household contacts of cholera patients during the week after the index patient seeks hospital care than it is for the general population. To initiate a standard of care for this high-risk population, we developed Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7), which promotes hand washing with soap and treatment of water. To test CHoBI7, we conducted a randomized controlled trial among 219 intervention household contacts of 82 cholera patients and 220 control contacts of 83 cholera patients in Dhaka, Bangladesh, during 2013-2014. Intervention contacts had significantly fewer symptomatic Vibrio cholerae infections than did control contacts and 47% fewer overall V. cholerae infections. Intervention households had no stored drinking water with V. cholerae and 14 times higher odds of hand washing with soap at key events during structured observation on surveillance days 5, 6, or 7. CHoBI7 presents a promising approach for controlling cholera among highly susceptible household contacts of cholera patients.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Cholera Cross Infection Family Characteristics Female Hospitals Humans Hygiene Infant Male Middle Aged Odds Ratio Research Vibrio Cholerae Water Purification Young Adult

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• Source:
  Emerg Infect Dis. 22(2):233-241.
• Pubmed ID:
  26811968
• Pubmed Central ID:
  PMC4734520
• Document Type:
  Journal Article
• Funding:
  K01 AI110526/AI/NIAID NIH HHS/United States
• Place as Subject:
  Bangladesh
• Location:
  Asia
• Volume:
  22
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b6178998d6fb7d2ab7b2f755a93ec01dba5484178837ff04f68464d493f44948
• Download URL:
  https://stacks.cdc.gov/view/cdc/37991/cdc_37991_DS1.pdf
• File Type:
  [PDF - 602.35 KB ]