Epidemiology of Serotype 1 Invasive Pneumococcal Disease, South Africa, 2003–2013
Published Date:Feb 2016
Source:Emerg Infect Dis. 22(2):261-270.
Corporate Authors:for the Group for Enteric, Respiratory, and Meningeal Disease Surveillance in South Africa (GERMS-SA)
Epidemiology Of Serotype 1 Invasive Pneumococcal Disease, South Africa, 2003–2013
History, 21st Century
Pneumococcal Conjugate Vaccine
Pubmed Central ID:PMC4734528
Funding:U2G PS001328/PS/NCHHSTP CDC HHS/United States
5U2GPS001328/PHS HHS/United States
Description:In South Africa, 7-valent pneumococcal conjugate vaccine (PCV) was introduced in April 2009 and replaced with 13-valent PCV in April 2011. We describe the epidemiology of serotype 1 Streptococcus pneumoniae disease during the pre- and post-PCV eras (2003-2013). Using laboratory-based invasive pneumococcal disease (IPD) surveillance, we calculated annual incidences, identified IPD clusters, and determined serotype 1-associated factors. Of 46,483 IPD cases, 4,544 (10%) were caused by serotype 1. Two clusters of serotype 1 infection were detected during 2003-2004 and 2008-2012, but incidence decreased after 2011. Among children <5 years of age, those who had non-serotype 1 IPD had shorter hospital stays, fewer cases of penicillin-nonsusceptible disease, and lower HIV prevalence and in-hospital death rates than did those with serotype 1 IPD; similar factors were noted for older patients. Serotype 1 IPD had distinctive clinical features in South Africa, and annual incidences fluctuated, with decreases noted after the introduction of PCV13.
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