Epidemiology of Serotype 1 Invasive Pneumococcal Disease, South Africa, 2003–2013

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  von Mollendorf, Claire ; Cohen, Cheryl ; Tempia, Stefano ; Meiring, Susan ; de Gouveia, Linda ; Quan, Vanessa ; Lengana, Sarona ; Karstaedt, Alan ; Dawood, Halima ; Seetharam, Sharona ; Lekalakala, Ruth ; Madhi, Shabir A. ; Klugman, Keith P. ; von Gottberg, Anne
• Corporate Authors:
  for the Group for Enteric, Respiratory, and Meningeal Disease Surveillance in South Africa (GERMS-SA)
• Description:
  In South Africa, 7-valent pneumococcal conjugate vaccine (PCV) was introduced in April 2009 and replaced with 13-valent PCV in April 2011. We describe the epidemiology of serotype 1 Streptococcus pneumoniae disease during the pre- and post-PCV eras (2003-2013). Using laboratory-based invasive pneumococcal disease (IPD) surveillance, we calculated annual incidences, identified IPD clusters, and determined serotype 1-associated factors. Of 46,483 IPD cases, 4,544 (10%) were caused by serotype 1. Two clusters of serotype 1 infection were detected during 2003-2004 and 2008-2012, but incidence decreased after 2011. Among children <5 years of age, those who had non-serotype 1 IPD had shorter hospital stays, fewer cases of penicillin-nonsusceptible disease, and lower HIV prevalence and in-hospital death rates than did those with serotype 1 IPD; similar factors were noted for older patients. Serotype 1 IPD had distinctive clinical features in South Africa, and annual incidences fluctuated, with decreases noted after the introduction of PCV13.
• Subjects:
  Adolescent Adult Aged Child Child, Preschool History, 21St Century Hospitalization Humans Incidence Infant Infant, Newborn Middle Aged Mortality Odds Ratio Pneumococcal Infections Pneumococcal Vaccines Research Risk Factors Serogroup Spatio-Temporal Analysis Young Adult

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• Source:
  Emerg Infect Dis. 22(2):261-270.
• Pubmed ID:
  26812214
• Pubmed Central ID:
  PMC4734528
• Document Type:
  Journal Article
• Funding:
  U2G PS001328/PS/NCHHSTP CDC HHS/United States ; 5U2GPS001328/PHS HHS/United States
• Place as Subject:
  South Africa
• Location:
  Africa
• Volume:
  22
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:413285037655a106108154db629af62f6c2ea4837f85adf1743535730a7f8525
• Download URL:
  https://stacks.cdc.gov/view/cdc/37990/cdc_37990_DS1.pdf
• File Type:
  [PDF - 664.50 KB ]