i
Epidemiology of Serotype 1 Invasive Pneumococcal Disease, South Africa, 2003–2013
-
Feb 2016
-
-
Source: Emerg Infect Dis. 22(2):261-270.
[PDF-664.50 KB]
Details:
-
Alternative Title:Emerg Infect Dis
-
Personal Author:
-
Corporate Authors:
-
Description:In South Africa, 7-valent pneumococcal conjugate vaccine (PCV) was introduced in April 2009 and replaced with 13-valent PCV in April 2011. We describe the epidemiology of serotype 1 Streptococcus pneumoniae disease during the pre- and post-PCV eras (2003-2013). Using laboratory-based invasive pneumococcal disease (IPD) surveillance, we calculated annual incidences, identified IPD clusters, and determined serotype 1-associated factors. Of 46,483 IPD cases, 4,544 (10%) were caused by serotype 1. Two clusters of serotype 1 infection were detected during 2003-2004 and 2008-2012, but incidence decreased after 2011. Among children <5 years of age, those who had non-serotype 1 IPD had shorter hospital stays, fewer cases of penicillin-nonsusceptible disease, and lower HIV prevalence and in-hospital death rates than did those with serotype 1 IPD; similar factors were noted for older patients. Serotype 1 IPD had distinctive clinical features in South Africa, and annual incidences fluctuated, with decreases noted after the introduction of PCV13.
-
Subjects:
-
Source:
-
Pubmed ID:26812214
-
Pubmed Central ID:PMC4734528
-
Document Type:
-
Funding:
-
Place as Subject:
-
Location:
-
Volume:22
-
Issue:2
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
