Interaction between common breast cancer susceptibility variants, genetic ancestry, and non-genetic risk factors in Hispanic women

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Fejerman, Laura ; Stern, Mariana C. ; John, Esther M. ; Torres-Mejía, Gabriela ; Hines, Lisa M. ; Wolff, Roger K. ; Baumgartner, Kathy B. ; Giuliano, Anna R. ; Ziv, Elad ; Pérez-Stable, Eliseo J. ; Slattery, Martha L.
• Description:
  Background
  
  Most genetic variants associated with breast cancer risk have been discovered in women of European ancestry, and only a few genome-wide association studies (GWAS) have been conducted in minority groups. This research disparity persists in post-GWAS gene-environment interaction analyses. We tested the interaction between hormonal and lifestyle risk factors for breast cancer, and ten GWAS-identified single nucleotide polymorphisms (SNPs) among 2,107 Hispanic women with breast cancer and 2,587 unaffected controls, to gain insight into a previously reported gene by ancestry interaction in this population.
  
  Methods
  
  We estimated genetic ancestry with a set of 104 ancestry-informative markers selected to discriminate between Indigenous American and European ancestry. We used logistic regression models to evaluate main effects and interactions.
  
  Results
  
  We found that the rs13387042-2q35(G/A) SNP was associated with breast cancer risk only among postmenopausal women who never used hormone therapy [per A allele odds ratio (OR): 0.94 (95% confidence interval 0.74–1.20), 1.20 (0.94–1.53) and 1.49 (1.28–1.75) for current, former and never hormone therapy users, respectively, P-interaction 0.002] and premenopausal women who breastfed >12 months [OR: 1.01 (0.72–1.42), 1.19 (0.98–1.45) and 1.69 (1.26–2.26) for never, <12 months, and >12 months breastfeeding, respectively, P-interaction 0.014].
  
  Conclusions
  
  The correlation between genetic ancestry, hormone replacement therapy use, and breastfeeding behavior partially explained a previously reported interaction between a breast cancer risk variant and genetic ancestry in Hispanic women.
  
  Impact
  
  These results highlight the importance of understanding the interplay between genetic ancestry, genetics, and non-genetic risk factors and their contribution to breast cancer risk.
  
  
• Subjects:
  Adult Breast Neoplasms Female Gene-Environment Interaction Genetic Predisposition To Disease Genome-Wide Association Study Hispanic Or Latino Humans Indians, North American Life Style Middle Aged Polymorphism, Single Nucleotide Risk Factors

  More +
• Source:
  Cancer Epidemiol Biomarkers Prev. 24(11):1731-1738.
• Pubmed ID:
  26364163
• Pubmed Central ID:
  PMC4633366
• Document Type:
  Journal Article
• Funding:
  K01 CA160607/CA/NCI NIH HHS/United States ; CA77305/CA/NCI NIH HHS/United States ; R01 CA63446/CA/NCI NIH HHS/United States ; HHSN261201000036C/PHS HHS/United States ; U54 CA153511/CA/NCI NIH HHS/United States ; CA078682/CA/NCI NIH HHS/United States ; P30-AG15272/AG/NIA NIH HHS/United States ; P30 AG015272/AG/NIA NIH HHS/United States ; 1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; R01 CA140002/CA/NCI NIH HHS/United States ; CA120120/CA/NCI NIH HHS/United States ; CA078552/CA/NCI NIH HHS/United States ; CA 160607/CA/NCI NIH HHS/United States ; N01-PC-67000/PC/NCI NIH HHS/United States ; CA14002/CA/NCI NIH HHS/United States ; CA078762/CA/NCI NIH HHS/United States ; R01 CA120120/CA/NCI NIH HHS/United States ; K24 CA169004/CA/NCI NIH HHS/United States ; CA63446/CA/NCI NIH HHS/United States ; CA078802/CA/NCI NIH HHS/United States
• Volume:
  24
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eb71ded90289631617112ec5c4c5294810118e4674a697435b12f7b678551c09
• Download URL:
  https://stacks.cdc.gov/view/cdc/37797/cdc_37797_DS1.pdf
• File Type:
  [PDF - 351.22 KB ]