Details:

Alternative Title:
Brain Res
Publisher's site:
http://dx.doi.org/10.1016/j.brainres.2015.09.026
Personal Author:
Kiedrowski, Megan ; Waugh, Stacey ; Miller, Roger ; Johnson, Claud ; Krajnak, Kristine
Kiedrowski, Megan ; Waugh, Stacey ; Miller, Roger ; Johnson, Claud ; Krajnak, Kristine Less -
Description:
Exposure to hand-transmitted vibration in the work-place can result in the loss of sensation and pain in workers. These effects may be exacerbated by pre-existing conditions such as diabetes or the presence of primary Raynaud's phenomena. The goal of these studies was to use an established model of vibration-induced injury in Zucker rats. Lean Zucker rats have a normal metabolic profile, while obese Zucker rats display symptoms of metabolic disorder or Type II diabetes. This study examined the effects of vibration in obese and lean rats. Zucker rats were exposed to 4h of vibration for 10 consecutive days at a frequency of 125 Hz and acceleration of 49 m/s(2) for 10 consecutive days. Sensory function was checked using transcutaneous electrical stimulation on days 1, 5 and 9 of the exposure. Once the study was complete the ventral tail nerves, dorsal root ganglia and spinal cord were dissected, and levels of various transcripts involved in sensorineural dysfunction were measured. Sensorineural dysfunction was assessed using transcutaneous electrical stimulation. Obese Zucker rats displayed very few changes in sensorineural function. However they did display significant changes in transcript levels for factors involved in synapse formation, peripheral nerve remodeling, and inflammation. The changes in transcript levels suggested that obese Zucker rats had some level of sensory nerve injury prior to exposure, and that exposure to vibration activated pathways involved in injury and re-innervation.
Subjects:
[+]
Animals Article Biophysics Chemokine CCL2 Disease Models, Animal Ganglia, Spinal Gene Expression Regulation Hyperalgesia Interleukin-1beta Male Metabolic Disorder Metabolic Syndrome Neuralgia Neuropathic Pain Nitric Oxide Synthase Type I Rats Rats, Zucker Receptors, Adrenergic, Alpha-2 RNA, Messenger Time Factors Transcutaneous Electric Nerve Stimulation Tyrosine Vibration Zucker Rat
Source:
Brain Res. 1627:216-224
Pubmed ID:
26433044
Pubmed Central ID:
PMC4725191
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHSUnited States/
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:57f5880fd04afecc99a21ba9417bed2ada15dc9885c13d8faf9691c76222a1b9
Download URL:
https://stacks.cdc.gov/view/cdc/37634/cdc_37634_DS1.pdf
File Type:

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