Details:

Alternative Title:
Epidemiology
Publisher's site:
http://dx.doi.org/10.1097/EDE.0b013e31829443ee
Personal Author:
Fitz-Simon, Nicola ; Fletcher, Tony ; Luster, Michael I. ; Steenland, Kyle ; Calafat, Antonia M. ; ... More +
Fitz-Simon, Nicola ; Fletcher, Tony ; Luster, Michael I. ; Steenland, Kyle ; Calafat, Antonia M. ; Kato, Kayoko ; Armstrong, Ben Less -
Description:
Background

Several epidemiological cross-sectional studies have found positive associations between serum concentrations of lipids and perfluorooctanoic acid (PFOA, or C8). A longitudinal study should be less susceptible to biases from uncontrolled confounding or reverse causality.

Methods

We investigated the association between within-individual changes in serum PFOA and perfluorooctanesulfonic acid (PFOS) and changes in serum lipid levels (low-density lipoprotein [LDL] cholesterol, high-density lipoprotein cholesterol, total cholesterol, and triglycerides) over a 4.4-year period. The study population consisted of 560 adults living in parts of Ohio and West Virginia where public drinking water had been contaminated with PFOA. They had participated in a cross-sectional study in 2005–2006, and were followed up in 2010, by which time exposure to PFOA had been substantially reduced.

Results

Overall serum concentrations of PFOA and PFOS fell by half from initial geometric means of 74.8 and 18.5 ng/mL, respectively, with little corresponding change in LDL cholesterol (mean increase 1.8%, standard deviation 26.6%). However, there was a tendency for people with greater declines in serum PFOA or PFOS to have greater LDL decrease. For a person whose serum PFOA fell by half, the predicted fall in LDL cholesterol was 3.6% (95% confidence interval = 1.5–5.7%). The association with a decline in PFOS was even stronger, with a 5% decrease in LDL (2.5–7.4%).

Conclusions

Our findings from this longitudinal study support previous evidence from cross-sectional studies of positive associations between PFOA and PFOS in serum and LDL cholesterol.


Subject:
[+]
Adult
Alkanesulfonic Acids
Article
Caprylates
Female
Fluorocarbons
Humans
Lipids
Longitudinal Studies
Male
Middle Aged
Time Factors
Young Adult

Source:
Epidemiology. 24(4):569-576.
Pubmed ID:
23685825
Pubmed Central ID:
PMC4724201
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:d4379ad9a5a6eb1483f4212116eb4049650c916c02a9096d41f30c735d819f83
File Type:

Supporting Files

• 	NIHMS742854-supplement-Appendix.doc	doc
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  	nihms742854f1.gif	gif
  	nihms742854f1.jpg	jpeg
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