Waking State: Rapid Variations Modulate Neural and Behavioral Responses

Details

• Alternative Title:
  Neuron
• Personal Author:
  McGinley, Matthew J. ; Vinck, Martin ; Reimer, Jacob ; Batista-Brito, Renata ; Zagha, Edward ; Cadwell, Cathryn R. ; Tolias, Andreas S. ; Cardin, Jessica A. ; McCormick, David A.
• Description:
  The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by which optimal sensory encoding and behavioral performance are achieved. Fluctuations in state, as indexed by pupillometry, impact both the "signal" (sensory evoked response) and the "noise" (spontaneous activity) of cortical responses. By taking these fluctuations into account, neural response (co)variability is significantly reduced, revealing the brain to be more reliable and predictable than previously thought.
• Subjects:
  Action Potentials Animals Article Brain Humans Motor Activity Nerve Net Neurons Time Factors Wakefulness
• Source:
  Neuron. 87(6):1143-1161.
• Pubmed ID:
  26402600
• Pubmed Central ID:
  PMC4718218
• Document Type:
  Journal Article
• Funding:
  5R01N2026143/PHS HHS/United States ; DP1 EY023176/EY/NEI NIH HHS/United States ; DP1 OD008301/OD/NIH HHS/United States ; DP1EY023176/DP/NCCDPHP CDC HHS/United States ; DP1OD008301/OD/NIH HHS/United States ; F30 MH095440/MH/NIMH NIH HHS/United States ; F30MH095440/MH/NIMH NIH HHS/United States ; F32 DC012449/DC/NIDCD NIH HHS/United States ; P30EY002520/EY/NEI NIH HHS/United States ; R00 EY018407/EY/NEI NIH HHS/United States ; R01 EY022951/EY/NEI NIH HHS/United States ; R01 EY022951/EY/NEI NIH HHS/United States ; R01 NS026143/NS/NINDS NIH HHS/United States ; T32 GM007330/GM/NIGMS NIH HHS/United States ; T32EB006350/EB/NIBIB NIH HHS/United States ; T32EY07001/EY/NEI NIH HHS/United States ; T32GM007330/GM/NIGMS NIH HHS/United States
• Volume:
  87
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:034e52555a12689fe43f6e3493d652a171f09b6eae5d0f88611922e299a45fbf
• Download URL:
  https://stacks.cdc.gov/view/cdc/37568/cdc_37568_DS1.pdf
• File Type:
  [PDF - 3.04 MB ]