Details:

Alternative Title:
Neuron
Publisher's site:
http://dx.doi.org/10.1016/j.neuron.2015.08.003
Personal Author:
Sauerbrei, Britton A. ; Lubenov, Evgueniy V. ; Siapas, Athanassios G.
Sauerbrei, Britton A. ; Lubenov, Evgueniy V. ; Siapas, Athanassios G. Less -
Description:
The cerebellum is a prominent vertebrate brain structure that is critically involved in sensorimotor function. During locomotion, cerebellar Purkinje cells are rhythmically active, shaping descending signals and coordinating commands from higher brain areas with the step cycle. However, the variation in this activity across steps has not been studied, and its statistical structure, afferent mechanisms, and relationship to behavior remain unknown. Here, using multi-electrode recordings in freely moving rats, we show that behavioral variables systematically influence the shape of the step-locked firing rate. This effect depends strongly on the phase of the step cycle and reveals a functional clustering of Purkinje cells. Furthermore, we find a pronounced disassociation between patterns of variability driven by the parallel and climbing fibers. These results suggest that Purkinje cell activity not only represents step phase within each cycle but also is shaped by behavior across steps, facilitating control of movement under dynamic conditions.
Subject:
[+]
Action Potentials
Animals
Article
Locomotion
Male
Purkinje Cells
Rats
Rats, Long-Evans

Source:
Neuron. 87(4):840-852.
Pubmed ID:
26291165
Pubmed Central ID:
PMC4708059
Document Type:
Journal Article
Funding:
1DP1OD008255/OD/NIH HHS/United States ; 5DP1MH099907/DP/NCCDPHP CDC HHS/United States ; DP1 MH099907/MH/NIMH NIH HHS/United States ; DP1 OD008255/OD/NIH HHS/United States
1DP1OD008255/OD/NIH HHS/United States ; 5DP1MH099907/DP/NCCDPHP CDC HHS/United States ; DP1 MH099907/MH/NIMH NIH HHS/United States ; DP1 OD008255/OD/NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:ffb293b642d82b6e1fbf8fbbb841b35230196316cd2f5ab262b5fb9902f66e57
File Type:

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