Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis

Yao, San-qiao; Rojanasakul, Liying Wang; Chen, Zhi-yuan; Xu, Ying-jun; Bai, Yu-ping; Chen, Gang; Zhang, Xi-ying; Zhang, Chun-min; Yu, Yan-qin; Shen, Fu-hai; Yuan, Ju-xiang; Chen, Jie; He, Qin-cheng

doi:10.1007/s10495-011-0647-4

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Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis

Published Date:

Dec 2011

Publisher's site:

http://dx.doi.org/10.1007/s10495-011-0647-4 New Site Icon

Source:

Apoptosis. 16(12):1195-1204.

[PDF-889.16 KB]

Details:

Alternative Title:

Apoptosis

Personal Author:

Yao, San-qiao ; Rojanasakul, Liying Wang ; Chen, Zhi-yuan ; Xu, Ying-jun ; Bai, Yu-ping ; ... More ▼

Description:

In vitro and in vivo studies have demonstrated that lung cell apoptosis is associated with lung fibrosis; however the relationship between apoptosis of alveolar macrophages (AMs) and human silicosis has not been addressed. In the present study, AM apoptosis was determined in whole-lung lavage fluid from 48 male silicosis patients, 13 male observers, and 13 male healthy volunteers. The relationships between apoptosis index (AI) and silica exposure history, soluble Fas (sFas)/membrane-bound Fas (mFas), and caspase-3/caspase-8 were analyzed. AI, mFas, and caspase-3 were significantly higher in lung lavage fluids from silicosis patients than those of observers or healthy volunteers, but the level of sFas demonstrated a decreasing trend. AI was related to silica exposure, upregulation of mFas, and activation of caspase-3 and -8, as well as influenced by smoking status after adjusting for confounding factors. These results indicate that AM apoptosis could be used as a potential biomarker for human silicosis, and the Fas/FasL pathway may regulate this process. The present data from human lung lavage samples may help to understand the mechanism of silicosis and in turn lead to strategies for preventing or treating this disease.

Subject:

[+]

Pubmed ID:

21910009

Pubmed Central ID:

PMC4707682

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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