Cross-sectional Study of Respiratory Symptoms, Spirometry and Immunologic Sensitivity in Epoxy Resin Workers
Published Date:Nov 10 2015
Source:Clin Transl Sci. 8(6):722-728.
Forced Expiratory Volume
Surveys And Questionnaires
Pubmed Central ID:PMC4703542
Funding:T42 OH009229/OH/NIOSH CDC HHS/United States
UL1 RR025780/RR/NCRR NIH HHS/United States
UL1 TR001082/TR/NCATS NIH HHS/United States
Description:An epoxy resin worker developed hypersensitivity pneumonitis requiring lung transplantation and had an abnormal blood lymphocyte proliferation test (LPT) to an epoxy hardener. We assessed the prevalence of symptoms, abnormal spirometry, and abnormal epoxy resin LPT results in epoxy resin workers compared to unexposed workers.|Participants completed questionnaires and underwent spirometry. We collected blood for epoxy resin LPT and calculated stimulation indices for five epoxy resin products.|We compared 38 exposed to 32 unexposed workers. Higher exposed workers were more likely to report cough (OR 10.86, [1.23-infinity], p = 0.030) or wheeze (OR 4.44, [1.00-22.25], p = 0.049) than unexposed workers, even controlling for smoking. Higher exposed workers were more likely to have abnormal FEV1 than unexposed workers (OR 10.51, [0.86-589.9], p = 0.071), although not statistically significant when adjusted for smoking. There were no differences in proportion of abnormal epoxy resin system LPTs between exposed and unexposed workers.|In summary, workers exposed to epoxy resin system chemicals were more likely to report respiratory symptoms and have abnormal FEV1 than unexposed workers. Use of epoxy resin LPT was not helpful as a biomarker of exposure and sensitization.
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