Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Personal Author:
Munger, Ronald G. ; Tamura, Tsunenobu ; Johnston, Kelley E. ; Feldkamp, Marcia L. ; Pfister, Roxane ; ... More +
Munger, Ronald G. ; Tamura, Tsunenobu ; Johnston, Kelley E. ; Feldkamp, Marcia L. ; Pfister, Roxane ; Cutler, Richard ; Murtaugh, Maureen A. ; Carey, John C. Less -
Description:
BACKGROUND

Maternal folate intake and related biomarkers have been inconsistently associated with a risk of oral clefts.

METHODS

Maternal concentrations of plasma folate (PF) and erythrocyte folate (EF), plasma pyridoxal-5′-phosphate (PLP; active vitamin B6) and total plasma homocysteine (tHcy) were measured in a Utah study with 347 cases and 469 controls.

RESULTS

Risk of all clefts combined, including cleft lip with or without cleft palate (CL/P) and cleft palate only (CP), was 65% lower in the highest versus lowest PF quartile (odds ratio [OR], 0.35; 95% confidence interval [CI], 0.23–0.53; p-trend < 0.001). Results remained significant in the subgroups with isolated CL/P and CP (p-trend < 0.001 in each). EF results were similar. In the highest versus lowest PLP quartile, risk of CP with other malformations was lower (OR, 0.25; 95% CI, 0.07–0.95); however, no other associations were significant for PLP or tHcy. Differences in mean bio-marker levels between cases and controls widened with an increasing interval between delivery and maternal blood collection. Decreased cleft risk with increasing quartiles of PF, EF, and PLP and decreasing tHcy was more apparent in mothers with a longer versus shorter interval between the index child delivery and blood collection.

CONCLUSION

Low maternal blood folate concentration was associated with an increased risk of clefts, and the differences in mean case and control PF, EF, PLP, and tHcy concentrations widened over time. Additional mechanistic studies are warranted to elucidate whether an acquired or inherited disorder of folate metabolism plays a role in the etiology of clefts.


Subjects:
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Adult Article Biomarkers Carbon Case-Control Studies Cleft Lip Cleft Palate Female Folic Acid Folic Acid Deficiency Humans Infant, Newborn Male Metabolism, Inborn Errors Mothers Pregnancy Risk Factors Young Adult
Source:
Birth Defects Res A Clin Mol Teratol. 91(3):153-161.
Pubmed ID:
21290562
Pubmed Central ID:
PMC4703080
Document Type:
Journal Article
Funding:
1R21-DE016877/DE/NIDCR NIH HHS/United States ; 1UO1DD000698/DD/NCBDD CDC HHS/United States ; 5-RO1-HD39061/HD/NICHD NIH HHS/United States ; R01 HD039061/HD/NICHD NIH HHS/United States
1R21-DE016877/DE/NIDCR NIH HHS/United States ; 1UO1DD000698/DD/NCBDD CDC HHS/United States ; 5-RO1-HD39061/HD/NICHD NIH HHS/United States ; R01 HD039061/HD/NICHD NIH HHS/United States Less -
Place as Subject:
Utah
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:76537d0d5231c00ab1aed3f7f8371a745e744700f94cefe672561f50dc9a049f
Download URL:
https://stacks.cdc.gov/view/cdc/37356/cdc_37356_DS1.pdf
File Type:

Supporting Files

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