Multiorgan WU Polyomavirus Infection in Bone Marrow Transplant Recipient

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Siebrasse, Erica A. ; Nguyen, Nang L. ; Willby, Melisa J. ; Erdman, Dean D. ; Menegus, Marilyn A. ; Wang, David
• Description:
  WU polyomavirus (WUPyV) was detected in a bone marrow transplant recipient with severe acute respiratory distress syndrome who died in 2001. Crystalline lattices of polyomavirus-like particles were observed in the patient's lung by electron microscopy. WUPyV was detected in the lung and other tissues by real-time quantitative PCR and identified in the lung and trachea by immunohistochemistry. A subset of WUPyV-positive cells in the lung had morphologic features of macrophages. Although the role of WUPyV as a human pathogen remains unclear, these results clearly demonstrate evidence for infection of respiratory tract tissues in this patient.
• Subjects:
  Bone Marrow Transplantation Child, Preschool Female Humans Lung Polyomavirus Polyomavirus Infections Respiratory Tract Infections Transplant Recipients
• Source:
  Emerg Infect Dis. 22(1):24-31.
• Pubmed ID:
  26691850
• Pubmed Central ID:
  PMC4696717
• Document Type:
  Journal Article
• Volume:
  22
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:4e6e483c7f23ed199cd449a85a957179dcb92ed964316aa6676edff430ea3b48
• Download URL:
  https://stacks.cdc.gov/view/cdc/37298/cdc_37298_DS1.pdf
• File Type:
  [PDF - 616.93 KB ]