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Effect of diabetes on tuberculosis presentation and outcomes in Kiribati
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5 2015
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Source: Trop Med Int Health. 20(5):643-649
[PDF-141.11 KB]
Details:
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Alternative Title:Trop Med Int Health
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Personal Author:
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Description:OBJECTIVES
To determine the association between diabetes and the clinical features and treatment outcomes of TB in Kiribati.
METHODS
We enrolled consecutive patients with TB who presented from August 2010 to February 2012 and compared clinical features and TB treatment outcomes for patients with and without diabetes, as measured by haemoglobin A1c assay. Poor outcome was defined as death, default or treatment failure, and good outcome as treatment success or cure.
RESULTS
Two hundred and seventy-five eligible persons with TB disease were enrolled; 101 (37%) had diabetes. TB patients with diabetes were more likely to have acid-fast bacilli (AFB) seen on sputum smear microscopy (RR: 1.3; 95% CI: 1.03–1.62). The risk of poor outcome did not differ between patients with or without diabetes (RR: 1.1; 95% CI: 0.5–2.7).
CONCLUSION
TB patients with diabetes are more likely than those without to have sputum with AFB on microscopy. This could increase transmission in the community. Early detection of TB by screening patients with diabetes, and the converse, could be important public health interventions where diabetes and TB are prevalent.
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Pubmed ID:25630576
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Pubmed Central ID:PMC4697448
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Volume:20
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Issue:5
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