Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
McNicholl, Janet M. ; Smith, Dawn K. ; Qari, Shoukat H. ; Hodge, Thomas.
McNicholl, Janet M. ; Smith, Dawn K. ; Qari, Shoukat H. ; Hodge, Thomas. Less -
Description:
Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AIDS, and an estimated 22 million people are infected with human immunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratory discoveries regarding HIV pathogenesis provided new hope for the prevention and treatment of HIV infection. One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. We also examine the effect of this discovery on medical and public health practices.
Subjects:
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Adult Alleles Amino Acid Sequence Base Sequence Child DNA Genetics, Population Hiv Hiv Infections Humans Molecular Sequence Data Molecular Structure Mutation Polymorphism, Genetic Receptors, Ccr5 Receptors, Cytokine Receptors, Hiv Research Article Sequence Deletion
Source:
Emerg Infect Dis. 3(3):261-271.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d54bc3f8700d518d2ff36c9b2c9cbb851cd9e63b4c58dcf9f86afc82666ba3f6
Download URL:
https://stacks.cdc.gov/view/cdc/3709/cdc_3709_DS1.pdf
File Type:

Supporting Files

• 	9284370.nxml	txt
  	license.txt	txt

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