Characterization of Frequency-Dependent Responses of the Vascular System to Repetitive Vibration

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Krajnak, Kristine ; Miller, G. Roger ; Waugh, Stacey ; Johnson, Claud ; Kashon, Michael L.
• Description:
  Objective
  
  Occupational exposure to hand-transmitted vibration can result in damage to nerves and sensory loss. The goal of this study was to assess the frequency-dependent effects of repeated bouts of vibration on sensory nerve function and associated changes in nerves.
  
  Methods
  
  The tails of rats were exposed to vibration at 62.5, 125, or 250 Hz (constant acceleration of 49m/s2) for 10 days. The effects on sensory nerve function, nerve morphology, and transcript expression in ventral tail nerves were measured.
  
  Results
  
  Vibration at all frequencies had effects on nerve function and physiology. However, the effects tended to be more prominent with exposure at 250 Hz.
  
  Conclusion
  
  Exposure to vibration has detrimental effects on sensory nerve function and physiology. However, many of these changes are more prominent at 250-Hz exposure than at lower frequencies.
  
  
• Subjects:
  Animals Disease Models, Animal Male Occupational Diseases Rats Rats, Sprague-Dawley Sensory Receptor Cells Tail Vascular System Injuries Vibration
• Source:
  J Occup Environ Med. 54(8):1010-1016.
• Pubmed ID:
  22785326
• Pubmed Central ID:
  PMC4678325
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  54
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:93657cd835364189455d4d70ae187c96fa4689069340aeab9640d4152e5f8a98
• Download URL:
  https://stacks.cdc.gov/view/cdc/36854/cdc_36854_DS1.pdf
• File Type:
  [PDF - 1.61 MB ]