Details:

Alternative Title:
Am J Hum Biol
Publisher's site:
http://dx.doi.org/10.1002/ajhb.22475
Personal Author:
Charles, Luenda E. ; Andrew, Michael E. ; Sarkisian, Khachatur ; Li, Shengqiao ; Mnatsakanova, Anna ; ... More +
Charles, Luenda E. ; Andrew, Michael E. ; Sarkisian, Khachatur ; Li, Shengqiao ; Mnatsakanova, Anna ; Violanti, John M. ; Wilson, Mark ; Gu, Ja K. ; Miller, Diane B. ; Burchfiel, Cecil M. ; Less -
Description:
Objective Low heart rate variability (HRV) has been linked to cardiovascular disease. Our objective was to examine the cross-sectional association between insulin and HRV. Methods Insulin levels were measured in 355 nondiabetic officers from the BCOPS study, following a 12 h fast. HRV was performed according to methods published by the task force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology for measurement and analysis of HRV. Mean values of high (HF) and low frequency (LF) HRV were compared across tertiles of insulin using ANOVA and ANCOVA; p-values were obtained from linear regression models. Results Higher mean levels of insulin were significantly associated with lower (i.e., worse) mean levels of HRV before and after risk-factor adjustment. The results for HF HRV (ms2) were as follows: 1st insulin (µU/ml) tertile (156.3; 95% confidence interval (CI) = 128.6–189.9); 2nd tertile (154.3; 95% CI = 124.3–191.5); 3rd tertile (127.9; 95% CI = 105.0–155.8), p for trend = 0.017. Results with LF HRV were similar to HF HRV. Insulin was also inversely and significantly associated with HRV among officers with BMI ≥25 kg/m2, with ≥25.5% body fat, and among those who reported low (More ▼ -->
Subject:
[+]
Adult
Cross-Sectional Studies
Electrocardiography
Female
Heart Rate
Humans
Immunoassay
Insulin
Luminescent Measurements
Male
Middle Aged
Police
Risk Factors
Sex Factors

Source:
Am J Hum Biol. 26(1):56-63 ;
Pubmed ID:
24136902
Pubmed Central ID:
PMC4657740
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ; 200-2003-01580/PHS HHS/United States ;
CC999999/Intramural CDC HHS/United States ; 200-2003-01580/PHS HHS/United States ; Less -
Place as Subject:
New York ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a225edc6cab0985ceb286f8d2f237c6dc1def110decd23968317b11faec4900f
File Type:

Supporting Files

• nihms737031.nxml

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