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Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China

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  • Alternative Title:
    BMC Research Notes
  • Personal Author:
    Guo, Xiuchan ; Zeng, Yi ; Deng, Hong ; Liao, Jian ; Zheng, Yuming ; Li, Ji ; Kessing, Bailey ; O'Brien, Stephen J
  • Description:
    Background ; Southern China is a major area for endemic nasopharyngeal carcinoma (NPC). Genetic factors as well as environmental factors play a role in development of NPC. To investigate the roles of previously described carcinogen metabolism gene variants for NPC susceptibility in a Han Chinese population, we conducted a case-control study in two independent study population groups afflicted with NPC in Guangdong and Guangxi Provinces of southern China. ; Methods ; Five single nucleotide polymorphisms (SNPs) of CYP2E1-rs2031920, CYP2E1-rs6413432, GSTP1-rs947894, MPO-rs2333227 and NQO1-rs1800566 were genotyped by PCR-based RFLP, sequencing and TaqMan assay in 358 NPC cases and 629 controls (phase I cohort). Logistic regression analysis was used to estimate odds ratios (OR) and 95% confidence intervals (CI). To confirm our results, sixteen tag SNPs for GSTP1, MPO, NQO1 (which 100% covered these genes), and 4 functional SNPs of CYP2E1 were genotyped in another cohort of 213 NPC cases and 230 controls (phase II cohort). ; Results ; No significant associations in NPC risk were observed for the five polymorphisms tested in the phase I cohort. In an additional stratified analysis for phase I, there was no significant association between cases and controls in NPC high risk population (EBV/IgA/VCA positive population). Analysis of 14 tagging SNPs within the same genes in an independent phase II cohort were in agreement with no SNPs significantly associated with NPC. ; Conclusions ; Our results suggest that polymorphism of CYP2E1, GSTP1, MPO and NQO1 genes does not contribute to overall NPC risk in a Han Chinese in southern China.
  • Subjects:
  • Source:
    BMC Research Notes. 2010; 3:212.
  • Document Type:
    Journal Article
  • Download URL:
    https://stacks.cdc.gov/view/cdc/3668/cdc_3668_DS1.pdf
  • File Type:
    Filetype[PDF - 248.13 KB]
  • Collection(s):
    CDC Public Access
  • Main Document Checksum:
    urn:sha256:5f1c5ad8f12599ee961389f612f4f67f39bac71f93acd4ec73884bf9082f3599
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