Details:

Alternative Title:
Am J Alzheimers Dis Other Demen
Publisher's site:
http://dx.doi.org/10.1177/1533317515602218
Personal Author:
Maddox, R.A. ; Blase, J.L. ; Mercaldo, N.D. ; Harvey, A.R. ; Schonberger, L.B. ; ... More +
Maddox, R.A. ; Blase, J.L. ; Mercaldo, N.D. ; Harvey, A.R. ; Schonberger, L.B. ; Kukull, W.A. ; Belay, E. D. ; Less -
Description:
Background Brain tissue analysis is necessary to confirm prion diseases. Clinically unsuspected cases may be identified through neuropathologic testing. Methods National Alzheimer’s Coordinating Center (NACC) Minimum and Neuropathologic Data Sets for 1984–2005 were reviewed. Eligible patients had dementia, underwent autopsy, had available neuropathologic data, belonged to a currently funded Alzheimer’s Disease Center (ADC), and were coded as having an Alzheimer’s disease clinical diagnosis or a non-prion disease etiology. For the eligible patients with neuropathology indicating prion disease, further clinical information, collected from the reporting ADC, determined whether prion disease was considered before autopsy. Results Of 6000 eligible patients in the NACC database, 7 (0.12%) were clinically unsuspected but autopsy confirmed prion disease cases. Conclusion The proportion of dementia patients with clinically unrecognized but autopsy confirmed prion disease was small. Besides confirming clinically suspected cases, neuropathology is useful to identify unsuspected, clinically atypical cases of prion disease.
Subject:
[+]
Aged
Aged, 80 And Over
Alzheimer Disease
Alzheimer’s Disease
Article
Autopsy
Creutzfeldt-Jakob Disease
Creutzfeldt-Jakob Syndrome
Dementia
Diagnosis
Female
Gerstmann-Straussler-Scheinker Disease
Humans
Male
Middle Aged
Prion Disease
Registries

Source:
Am J Alzheimers Dis Other Demen. 30(8):752-755. ;
Pubmed ID:
26320231
Pubmed Central ID:
PMC4651736
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ; U01 AG016976/AG/NIA NIH HHS/United States ;
CC999999/Intramural CDC HHS/United States ; U01 AG016976/AG/NIA NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:68ac2c6a23d9c7952d9cfd88cd7e59ecf18208b8ed4b20a4dad757ffa696ace5
File Type:

Supporting Files

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